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Electrophysiologic recurrent laryngeal nerve monitoring during thyroid and parathyroid surgery : international standards guideline statement Universiteit Gent
Intraoperative neural monitoring (IONM) during thyroid and parathyroid surgery has gained widespread acceptance as an adjunct to the gold standard of visual nerve identification. Despite the increasing use of IONM, review of the literature and clinical experience confirms there is little uniformity in application of and results from nerve monitoring across different centers. We provide a review of the literature and cumulative experience of the ...
Diastematomyelia and late onset presentation : a case report of a 72-year-old woman Universiteit Gent
BACKGROUND: We would like to present the case of a 72-year-old woman, in whom diastematomyelia was surprisingly discovered when looking for an explanation for her neurological and urological complaints. Diastematomyelia is a rare disease in the group of "spinal dysraphisms," mostly discovered at birth and very rare at advanced age. The clinical pattern could be seen in the general presentation of 'tethered cord' and there are 2 types of ...
Present and future of folate biofortification of crop plants Universiteit Gent
Spinal congenital dermal sinus in a chick embryo model Laboratory investigation Universiteit Hasselt
Object. The origin of spinal congenital dermal sinuses is not known. A local nondisjunction of the closing neural tube and the epidermal ectoderm is thought to be the cause of this malformation. In this experimental study, a nondisjunction was mimicked in chick embryos to create an animal model for the dermal sinus. Methods. A piece of amniotic tissue was implanted in the closing neural tube in ovo in chick embryos at 2 days of incubation. A ...
Where is the worm? Predictive modelling of the habitat preferences of the tube-building polychaete Lanice conchilega (Pallas, 1766) Instituut voor Landbouw-, Visserij- en Voedingsonderzoek
Grab samples to monitor the distribution of marine macrobenthic species (animals >1 mm, living in the sand) are time consuming and give only point based information. If the habitat preference of a species can be modelled, the spatial distribution can be predicted on a full coverage scale from the environmental variables. The modelling techniques Generalized Linear Models (GLM) and Artificial Neural Networks (ANN) were compared in their ...
Folic Acid Exposure Rescues Spina Bifida Aperta Phenotypes in Human Induced Pluripotent Stem Cell Model KU Leuven
Neural tube defects (NTDs) are severe congenital abnormalities, caused by failed closure of neural tube during early embryonic development. Periconceptional folic acid (FA) supplementation greatly reduces the risk of NTDs. However, the molecular mechanisms behind NTDs and the preventive role of FA remain unclear. Here, we use human induced pluripotent stem cells (iPSCs) derived from fetuses with spina bifida aperta (SBA) to study the ...
Validation methods for diffusion weighted magnetic resonance imaging in brain white matter Universiteit Gent
Magnetic resonance imaging or MRI is a powerful medical imaging technique. This non-invasive technique utilizes a strong static magnetic field and radio frequent electromagnetic waves to align the magnetic dipole moments of water molecules in the body. Images are created based on the local density of water molecules and their mutual interactions. MRI provides great contrast between soft tissues and is generally regarded to be a safe imaging ...
Epigenomic, Genomic, and Environmental Interactions of TET1 in Embryonic Development KU Leuven
The etiology of congenital malformations, particularly neural tube defects (NTDs), is complex, and involves a combination of genetic and environmental factors affecting each other. Understanding the relationship between intrinsic genetic factors and extrinsic environmental factors has been challenging. Here in this thesis, I describe my efforts to improve our understanding of the epigenome-gene-environment interaction model. Of particular ...