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Transient Receptor Potential (TRP) channels in Chemotherapy-Induced Peripheral Neuropathy (CIPN): Translational research from bench to bedside KU Leuven

Heleen Marynissen
For many cancer survivors, the burden of the disease extends beyond successful treatment. Often, chronic side effects affect patient's quality of life after treatment completion, e.g. chronic fatigue, fertility problems or chemotherapy-induced peripheral neuropathy (CIPN). The latter concerns a debilitating pathology in patients treated with specific chemotherapeutics agents, including platinum derivatives (oxaliplatin, cisplatin), taxanes ...

Brain Connectivity and Cognitive Flexibility in Nonirradiated Adult Survivors of Childhood Leukemia Vrije Universiteit Brussel KU Leuven

Thibo Billiet, Iris Elens, Charlotte Sleurs, Anne Uyttebroeck, Rudi D'Hooge, Jurgen Lemiere, Sabine Deprez

Background: This study aimed to assess functional and structural brain connectivity in adult childhood leukemia survivors and the link with cognitive functioning and previously identified risk factors such as intrathecal methotrexate dose and age at start of therapy. Methods: Thirty-one nonirradiated adult childhood leukemia survivors and 35 controls underwent cognitive testing and multimodal magnetic resonance imaging (resting state ...

EEG connectivity between the subgenual anterior cingulate and prefrontal cortices in response to antidepressant medication Vrije Universiteit Brussel Universiteit Gent

Tabitha A Iseger, Mayuresh S Korgaonkar, J Leon Kenemans, Stuart M Grieve, Chris Baeken, Martijn Arns

Antidepressant medication is the most common treatment for major depressive disorder (MDD), however, the precise working mechanism underlying these treatments remains unclear. Recent neuromodulation treatments demonstrate that direct stimulation of the dorsolateral prefrontal cortex (DLPFC), dorsomedial prefrontal cortex (DMPFC), and subgenual anterior cingulate (sgACC) relate to clinical improvement, suggesting connectivity alterations of ...