Interlaboratory diagnostic validation of conformation-sensitive capillary electrophoresis for mutation scanning Vrije Universiteit Brussel KU Leuven
BACKGROUND: Indirect alternatives to sequencing as a method for mutation scanning are of interest to diagnostic laboratories because they have the potential for considerable savings in both time and costs. Ideally, such methods should be simple, rapid, and highly sensitive, and they should be validated formally to a very high standard. Currently, most reported methods lack one or more of these characteristics. We describe the optimization and ...