Publicaties
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Development and validation of an HPLC-DAD method for rapid quantification of vasicine in Adhatoda vasica leaves and commercial products Universiteit Antwerpen
Leaves from Adhatoda vasica Nees, Acanthaceae (synonym Justicia adhatoda L.) have been widely used in traditional medicine for their beneficial effect in the treatment of respiratory diseases. Vasicine, the main quinazoline alkaloid in A. vasica, has been linked to its medicinal properties. The purpose of this work was to develop and validate a reliable analytical method for the quantification of vasicine in A. vasica leaves and commercially ...
Phytochemical characterisation and in vivo antilithiatic activity of the stems of Caesalpinia bahamensis (Brasilete) Universiteit Antwerpen
The aim of this work was to identify the main chemical constituents and to evaluate the antilithiatic activity of the aqueous and hydroalcoholic extracts of stems of Caesalpinia bahamensis Lam. Fractionation and isolation of constituents from the hydroalcoholic extract was carried out by flash chromatography and semi-preparative liquid chromatography. The antilithiatic activity of the aqueous and hydroalcoholic extracts was evaluated in Wistar ...
Marine seagrass extract of Thalassia testudinum suppresses colorectal tumor growth, motility and angiogenesis by autophagic stress and immunogenic cell death pathways Universiteit Antwerpen Universiteit Gent
Marine plants have become an inexhaustible reservoir of new phytopharmaceuticals for cancer treatment. We demonstrate in vitro/in vivo antitumor efficacy of a standardized polyphenol extract from the marine angiosperm Thalassia testudinum (TTE) in colon tumor cell lines (RKO, SW480, and CT26) and a syngeneic allograft murine colorectal cancer model. MTT assays revealed a dose-dependent decrease of cell viability of RKO, CT26, and SW480 cells ...
Natural products as a source of inspiration for novel inhibitors of advanced glycation endproducts (AGEs) formation Universiteit Antwerpen
Protein glycation, a post-translational modification found in biological systems, is often associated with a core defect in glucose metabolism. In particular, advanced glycation endproducts are complex heterogeneous sugar-derived protein modifications implicated in the progression of pathological conditions such as atherosclerosis, diabetic complications, skin diseases, rheumatism, hypertension, and neurodegenerative diseases. Undoubtedly, there ...
Multicomponent/cascade cyclization strategies (MCCS) for the synthesis of bioactive natural products and analogues KU Leuven
This thesis describes the application of multicomponent/cascade cyclization strategies (MCCS) for the synthesis of bioactive natural products and the main scaffolds exist in natural products. The research is based on the A3 coupling, and post-Ugi reactions developed previously in our laboratory. Chapter 1 gives an introduction to multicomponent reactions and cascade reactions. Giving the conception of the MCCS and highlighting the advantages of ...