A(BETA) AND TAU SHOW SYNERGISTIC TOXICITY IN YEAST KU Leuven
Disclosed herein are yeast cells which co-express: both ?? and tau and show greater cytotoxicity than cells expressing ?? or tau alone. These yeast cells model the synergistic effects of ?? and tau, and are useful for identifying compounds that reduce ?? and tau toxicity and for obtaining hyperphosphorylated tau species.