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NKT cells in Multiple Myeloma: a useful therapeutic tool? Vrije Universiteit Brussel
Natural killer T (NKT) cells are T cells with features of both NK and T cells. They recognize glycolipid antigens such as agalactosylceramide (aGalCer) presented by CD1d. NKT cells can produce either a Th1 (IFNg) or a Th2 (IL4) cytokine response. Studies of the in vivo role of NKT cells in MM are limited due to a lack of a suitable mouse model. Here we investigated the functionality of NKT cells in the immune competent 5T33MM model. NKT cell ...
Bacterial CD1d-restricted glycolipids induce IL-10 production by human regulatory T cells upon cross-talk with invariant NKT cells Vrije Universiteit Brussel Universiteit Gent
Invariant NKT (iNKT) cells and CD4(+)CD25(+)FOXP3(+) regulatory T cells (Tregs) are important immune regulatory T cells with Ag reactivity to glycolipids and peptides, respectively. However, the functional interplay between these cells in humans is poorly understood. We show that Tregs suppress iNKT cell proliferation induced by CD1d-restricted glycolipids, including bacterial-derived diacylglycerols, as well as by innate-like activation. ...
Tregs protect against invariant NKT cell-mediated autoimmune colitis and hepatitis Universiteit Gent Vlaams Instituut voor Biotechnologie
Immunomodulatory T cells play a pivotal role in protection against (auto)immune-mediated diseases that open perspectives for therapeutic modulation. However, how immune regulatory networks operate in vivo is less understood. To this end, we focused on FOXP3+CD4+CD25+ regulatory T cells (Tregs) and invariant natural killer T (iNKT) cells, two lymphocyte populations that independently regulate adaptive and innate immune responses. In vitro, a ...
The TLR7 agonist R848 alleviates allergic inflammation by targeting invariant NKT cells to produce IFN-gamma KU Leuven
It has been documented that TLR7 stimulation triggers not only antiviral responses, but also alleviates experimental asthma. Considering the implication of invariant NKT (iNKT) cells in both situations, we postulated that they might contribute to the anti-inflammatory effect of TLR7 ligands. We show in this study that spleen cells activated by the TLR7 agonist resiquimod (R848) attenuate allergic inflammation upon adoptive transfer when they are ...
The thymic microenvironment differentially regulates development and trafficking of invariant NKT cell sublineages KU Leuven Universiteit Gent
The regulatory role of the thymic microenvironment during trafficking and differentiation of the invariant NKT (iNKT) cell lineage remains poorly understood. In this study, we show that fractalkine receptor expression marks emigrating subpopulations of the NKT1, NKT2, and NKT17 sublineages in the thymus and peripheral organs of naive mice. Moreover, NKT1 sublineage cells can be subdivided into two subsets, namely NKT1(a) and NKT1(b), which ...