A non-parametric method to assess the presence of significant DNA-methylation in enrichment-based NGS data Universiteit Gent
Background: Over the last decade, DNA-methylation research has shifted from a gene-based approach to genome-wide analyses. DNA-methylation, featured by the enzymatic methylation of cytosines in a predominantly CpG-dinucleotide context, is an epigenetic process that is tightly associated with gene expression regulation. A novel generation of methodologies has enabled researchers to profile DNAmethylation in a genome-wide manner, e.g. by ...