Protein citrullination and NET formation do not contribute to the pathology of A20/TNFAIP3 mutant mice Universiteit Gent Vlaams Instituut voor Biotechnologie Universiteit Antwerpen
A20 serves as a critical brake on NF-kappa B-dependent inflammation. In humans, polymorphisms in or near the TNFAIP3/A20 gene have been linked to various inflammatory disorders, including systemic lupus erythematosus (SLE) and rheumatoid arthritis (RA). Experimental gene knockout studies in mice have confirmed A20 as a susceptibility gene for SLE and RA. Here, we examine the significance of protein citrullination and NET formation in the ...