Transcriptional adaptation of drug-tolerant Mycobacterium tuberculosis during treatment of human tuberculosis Instituut voor Tropische Geneeskunde
BACKGROUND:  Treatment initiation rapidly kills most drug-susceptible Mycobacterium tuberculosis, but a bacterial subpopulation tolerates prolonged drug exposure. We evaluated drug-tolerant bacilli in human sputum by comparing messenger RNA (mRNA) expression of drug-tolerant bacilli that survive the early bactericidal phase with treatment-naive bacilli.
METHODS:  M. tuberculosis gene expression was quantified via reverse-transcription ...