IgE recognition of multiple novel Api m 10 isoforms evaluated by protein array technology Universiteit Gent
Background: Until now, two splice variants of the honeybee venom allergen Api m 10 have been described. Variant 2 exhibits IgE reactivity with approximately 50% of honeybee venom sensitized patients. Our proteomic analysis of honeybee venom gave an indication for the existence of additional Api m 10 isoforms. As such, further research was needed to identify these isoforms and investigate the impact of protein heterogeneity on IgE recognition. ...