Publicaties
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Crossing the barrier: targeting epithelial receptors for antigen delivery to the mucosal immune system Universiteit Gent
Overview : the mucosal immune system Universiteit Gent
Mucosal priming of the murine immune system against Escherichia coli O157:H7 using Lactococcus lactis expressing a virulence antigen Universiteit Gent
Mucosal Immune Cell Numbers and Visceral Sensitivity in Patients With Irritable Bowel Syndrome: Is There Any Relationship? KU Leuven
OBJECTIVES:Repeated exposure to stress leads to mast cell degranulation, microscopic inflammation, and subsequent visceral hypersensitivity in animal models. To what extent this pathophysiological pathway has a role in patients with the irritable bowel syndrome (IBS) has not been properly investigated. The objective of this study was to assess the relationship between visceral hypersensitivity, microscopic inflammation, and the stress response ...
Oral administration of beta-1,3/1,6-glucan Macrogard fails to enhance the mucosal immune response following oral F4 fimbrial immunisation in gnotobiotic pigs KU Leuven Universiteit Gent
In this study gnotobiotic animals were used to see if the F4 fimbrial antigen of F4ac+ Escherichia coli is as immunogenic as in conventional pigs. In addition, the adjuvant effect of beta-1,3/1,6-glucans was analysed for the first time in germ-free domestic animals. Oral F4 immunisation of F4 receptor positive (F4R(+)) piglets was able to induce a systemic and mucosal immune response as conventional pigs, although less pronounced. Nevertheless, ...