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Malaria care in infants aged under six months in Uganda Instituut voor Tropische Geneeskunde Universiteit Antwerpen
BACKGROUND: Little information exists on malaria burden, artemisinin-based combination therapy (ACT) use, and malaria care provided to infants under six months of age. The perception that malaria may be rare in this age group has led to lack of clinical trials and evidence-based treatment guidelines. The objective of this study was to identify malaria parasitemia positivity rate (MPPR) among patients under six months, and practices and ...
Report of the seventeenth WHOPES working group meeting: WHO/HQ, Geneva, 15-19 September 2014: review of Alphacypermethrin 250 WG-SB, ICON MAXX, Netprotect LN Chlorfenapyr 240 SC Instituut voor Tropische Geneeskunde
Le paludisme de l'Afrique tropicale Instituut voor Tropische Geneeskunde
Patterns of selection on Plasmodium falciparum erythrocyte binding antigens after the colonisation of the New World Instituut voor Tropische Geneeskunde
Contrasting benefits of different artemisinin combination therapies as first-line malaria treatments using model-based cost-effectiveness analysis Instituut voor Tropische Geneeskunde
There are currently several recommended drug regimens for uncomplicated falciparum malaria in Africa. Each has different properties that determine its impact on disease burden. Two major antimalarial policy options are artemether-lumefantrine (AL) and dihydroartemisinin-piperaquine (DHA-PQP). Clinical trial data show that DHA-PQP provides longer protection against reinfection, while AL is better at reducing patient infectiousness. Here we ...
Use of artemisinin and its derivatives for the treatment of malaria in children Instituut voor Tropische Geneeskunde
Effectiveness of artesunate-amodiaquine vs. artemether-lumefantrine for the treatment of uncomplicated falciparum malaria in Nanoro, Burkina Faso Instituut voor Tropische Geneeskunde
OBJECTIVES: Artemisinin-based combination therapies (ACTs) are essential for the effective control of falciparum malaria in endemic countries. However, in most countries, such choice has been carried out without knowing their effectiveness when deployed in real-life conditions, that is, when treatment is not directly observed. We report here the results of a study assessing the effectiveness of the two ACTs currently recommended in Burkina Faso ...
Pharmacokinetics of co-formulated mefloquine and artesunate in pregnant and non-pregnant women with uncomplicated Plasmodium falciparum infection in Burkina Faso Instituut voor Tropische Geneeskunde Universiteit Antwerpen
OBJECTIVES: Mefloquine/artesunate has recently been developed as a fixed-dose combination, providing a promising rescue/alternative treatment for malaria during pregnancy. However, limited data are available on the effect of pregnancy on its pharmacokinetic properties. This study was conducted to assess the pharmacokinetic properties of mefloquine/carboxymefloquine and artesunate/dihydroartemisinin in pregnant and non-pregnant women with ...