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Lack of abundant core virome in Culex mosquitoes from a temperate climate region despite a mosquito species-specific virome Instituut voor Tropische Geneeskunde KU Leuven

L De Coninck, A Soto, LJ Wang, K De Wolf, N. Smitz, Isra Deblauwe, KCM Donfack, Ruth Müller, Leen Delang, Jelle Matthijnssens, et al.
In arthropod-associated microbial communities, insect-specific viruses (ISVs) are prevalent yet understudied due to limited infectivity outside their natural hosts. However, ISVs might play a crucial role in regulating mosquito populations and influencing arthropod-borne virus transmission. Some studies have indicated a core virome in mosquitoes consisting of mostly ISVs. Employing single mosquito metagenomics, we comprehensively profiled the ...

Favipiravir Does Not Inhibit Chikungunya Virus Replication in Mosquito Cells and Aedes aegypti Mosquitoes KU Leuven

Sofie Jacobs, Evelien Vanderlinden, Lieve Naesens, Leen Delang
Favipiravir (T-705) is a broad-spectrum antiviral drug that inhibits RNA viruses after intracellular conversion into its active form, T-705 ribofuranosyl 5'-triphosphate. We previously showed that T-705 is able to significantly inhibit the replication of chikungunya virus (CHIKV), an arbovirus transmitted by Aedes mosquitoes, in mammalian cells and in mouse models. In contrast, the effect of T-705 on CHIKV infection and replication in the ...

Stability of the Virome in Lab- and Field-Collected Aedes albopictus Mosquitoes across Different Developmental Stages and Possible Core Viruses in the Publicly Available Virome Data of Aedes Mosquitoes KU Leuven

Jelle Matthijnssens
Aedes mosquitoes can efficiently transmit many pathogenic arboviruses, placing a great burden on public health worldwide. In addition, they also carry a number of insect-specific viruses (ISVs), and it was recently suggested that some of these ISVs might form a stable species-specific "core virome" in mosquito populations. However, little is known about such a core virome in laboratory colonies and if it is present across different developmental ...

Anopheles gambiae densovirus (AgDNV) negatively affects Mayaro virus infection in Anopheles gambiae cells and mosquitoes Instituut voor Tropische Geneeskunde

Nadya Urakova, Marco Brustolin, Renuka E Joseph, Rebecca M Johnson, Sujit Pujhari, Jason L Rasgon

BACKGROUND: Recent studies demonstrate that insect-specific viruses can influence the ability of their mosquito hosts to become infected with and transmit arboviruses of medical and veterinary importance. The aim of this study was to evaluate the interactions between Anopheles gambiae densovirus (AgDNV) (Parvoviridae) (a benign insect-specific virus that infects An. gambiae mosquitoes) and Mayaro virus (MAYV) (Togaviridae) (an emerging human ...

NO BUG: biobased mosquitoes repellent personal protective equipment (PPE) Universiteit Gent

Lucy Wanjiru Ciera, Vincent Nierstrasz, Lieva Van Langenhove
In tropical regions (South America, Asia and Africa) diseases like malaria and dengue cause many deaths. These diseases are transmitted through mosquitoes bites (Anopheles sp. and Aedes aegypti respectively). The current practice to protect against transmission of these diseases is by use of mosquito repellents. Common mosquito repellents used today are synthetic in nature and are suspected or have been proved to be harmful to the user and ...

Entomo-virological surveillance strategy for dengue, Zika and chikungunya arboviruses in field-caught Aedes mosquitoes in an endemic urban area of the Northeast of Brazil Instituut voor Tropische Geneeskunde

Izabel Cristina dos Reis
Aedes spp. are considered the main vectors of dengue (DENV), Zika (ZIKV) and chikungunya (CHIKV) viruses in the world. Arbovirus detection in Aedes mosquitoes can alert authorities to possible outbreaks, reducing the impact of these diseases. The purpose of this study was to perform an operational strategy for virological surveillance of DENV, ZIKV and CHIKV in adult Aedes aegypti and Aedes albopictus mosquitoes captured at different key-sites ...

dynamAedes: a unified modelling framework for invasive Aedes mosquitoes Instituut voor Tropische Geneeskunde

Daniele Da Re, Wim Van Bortel, Friederike Reuss, Ruth Müller, Sebastien Boyer, Fabrizio Montarsi, Silvia Ciocchetta, Daniele Arnoldi, Giovanni Marini, Annapaola Rizzoli, et al.

Mosquito species belonging to the genus Aedes have attracted the interest of scientists and public health officers because of their capacity to transmit viruses that affect humans. Some of these species were brought outside their native range by means of trade and tourism and then colonised new regions thanks to a unique combination of eco-physiological traits. Considering mosquito physiological and behavioural traits to understand and ...

Implementation of surveillance of invasive mosquitoes in Belgium according to the ECDC guidelines Instituut voor Tropische Geneeskunde Universiteit Antwerpen

Isra Deblauwe, Charlotte Sohier, Francis Schaffner, Laurence Marrama Rakotoarivony, Marc Coosemans

BACKGROUND: In 2012, the new guidelines for the surveillance of IMS in Europe, produced by the European Centre for Disease Prevention and Control (ECDC), were tested in Belgium. This study aimed at (1) testing the usefulness and applicability in the field of the ECDC guidelines for the surveillance of IMS in Europe and (2) surveying IMS throughout Belgium.

METHODS: First, the scenarios, which Belgium is facing, were identified ...

Anopheles mosquitoes may drive invasion and transmission of Mayaro virus across geographically diverse regions Instituut voor Tropische Geneeskunde

Marco Brustolin, Sujit Pujhari, Cory A Henderson, Jason L Rasgon

The Togavirus (Alphavirus) Mayaro virus (MAYV) was initially described in 1954 from Mayaro County (Trinidad) and has been responsible for outbreaks in South America and the Caribbean. Imported MAYV cases are on the rise, leading to invasion concerns similar to Chikungunya and Zika viruses. Little is known about the range of mosquito species that are competent MAYV vectors. We tested vector competence of 2 MAYV genotypes in laboratory strains ...

An entomological review of invasive mosquitoes in Europe Instituut voor Tropische Geneeskunde

J.M. Medlock, K.M. Hansford, V. Versteirt, B Cull, H Kampen, D Fontenille, G Hendrickx, H. Zeller, Wim Van Bortel, F. Schaffner, et al.

Among the invasive mosquitoes registered all over the world, Aedes species are particularly frequent and important. As several of them are potential vectors of disease, they present significant health concerns for 21st century Europe. Five species have established in mainland Europe, with two (Aedes albopictus and Aedes japonicus) becoming widespread and two (Ae. albopictus and Aedes aegypti) implicated in disease transmission to humans in ...