Publicaties

1 - 10 of 208 resultaten

Zoek term:

Stability of the Virome in Lab- and Field-Collected Aedes albopictus Mosquitoes across Different Developmental Stages and Possible Core Viruses in the Publicly Available Virome Data of Aedes Mosquitoes KU Leuven

Chenyan Shi, Lu Zhao, Evans Atoni, Weifeng Zeng, Xiaomin Hu, Jelle Matthijnssens, Zhiming Yuan, Han Xia
Aedes mosquitoes can efficiently transmit many pathogenic arboviruses, placing a great burden on public health worldwide. In addition, they also carry a number of insect-specific viruses (ISVs), and it was recently suggested that some of these ISVs might form a stable species-specific "core virome" in mosquito populations. However, little is known about such a core virome in laboratory colonies and if it is present across different developmental ...

Differential Transmission of Antiviral Drug-Resistant Chikungunya Viruses by Aedes Mosquitoes KU Leuven

Leen Delang, Pei-Shi Yen, Thomas Vallet, Marie Vazeille, Marco Vignuzzi, Anna-Bella Failloux
The chikungunya virus (CHIKV) is transmitted by female Aedes aegypti and Aedes albopictus mosquitoes, mostly present in (sub)tropical regions. No antivirals are available to treat CHIKV infections. If antiviral drugs are proven efficient to treat CHIKV-infected patients, it will be pivotal to determine whether drug-resistant viruses can be transmitted from one human to another by their mosquito vectors. We orally infected Aedes aegypti ...

Cell-Fusing Agent Virus Reduces Arbovirus Dissemination in Aedes aegypti Mosquitoes In Vivo KU Leuven

Artem Baidaliuk, Elliott F Miot, Sebastian Lequime, Isabelle Moltini-Conclois, Fanny Delaigue, Stephanie Dabo, Laura B Dickson, Fabien Aubry, Sarah H Merkling, Van-Mai Cao-Lormeau, et al.
Aedes aegypti mosquitoes are the main vectors of arthropod-borne viruses (arboviruses) of public health significance, such as the flaviviruses dengue virus (DENV) and Zika virus (ZIKV). Mosquitoes are also the natural hosts of a wide range of viruses that are insect specific, raising the question of their influence on arbovirus transmission in nature. Cell-fusing agent virus (CFAV) was the first described insect-specific flavivirus, initially ...

Favipiravir Does Not Inhibit Chikungunya Virus Replication in Mosquito Cells and Aedes aegypti Mosquitoes KU Leuven

Sofie Jacobs, Lanjiao Wang, Ana Lucia Rosales Rosas, Ria Van Berwaer, Evelien Vanderlinden, Anna-Bella Failloux, Lieve Naesens, Leen Delang
Favipiravir (T-705) is a broad-spectrum antiviral drug that inhibits RNA viruses after intracellular conversion into its active form, T-705 ribofuranosyl 5'-triphosphate. We previously showed that T-705 is able to significantly inhibit the replication of chikungunya virus (CHIKV), an arbovirus transmitted by Aedes mosquitoes, in mammalian cells and in mouse models. In contrast, the effect of T-705 on CHIKV infection and replication in the ...

Detecting the population dynamics of an autosomal sex ratio distorter transgene in malaria vector mosquitoes Instituut voor Tropische Geneeskunde

Paola Pollegioni, Ace R North, Tania Persampieri, Alessandro Bucci, Roxana L Minuz, David Alexander Groneberg, Tony Nolan, Philippos-Aris Papathanos, Andrea Crisanti, Ruth Müller, et al.

The development of genetically modified (GM) mosquitoes and their subsequent field release offers innovative and cost-effective approaches to reduce mosquito-borne diseases, such as malaria. A sex-distorting autosomal transgene has been developed recently in G3 mosquitoes, a laboratory strain of the malaria vector Anopheles gambiae s.l. The transgene expresses an endonuclease called I-PpoI during spermatogenesis, which selectively cleaves the ...

Composition of Anopheles mosquitoes, their blood-meal hosts, and Plasmodium falciparum infection rates in three islands with disparate bed net coverage in Lake Victoria, Kenya KU Leuven

Edwin Ogola, Jandouwe Villinger, Danspaid Mabuka, David Omondi, Benedict Owino Orindi, James Mutunga, Vincent Owino, Daniel K Masiga
BACKGROUND: Small islands serve as potential malaria reservoirs through which new infections might come to the mainland and may be important targets in malaria elimination efforts. This study investigated malaria vector species diversity, blood-meal hosts, Plasmodium infection rates, and long-lasting insecticidal net (LLIN) coverage on Mageta, Magare and Ngodhe Islands of Lake Victoria in western Kenya, a region where extensive vector control is ...

Synthetic predator cues impair immune function and make the biological pesticide Bti more lethal for vector mosquitoes KU Leuven

Lin Op de Beeck, Lizanne Janssens, Robby Stoks
The control of vector mosquitoes is one of the biggest challenges facing humankind with the use of chemical pesticides often leading to environmental impact and the evolution of resistance. Although to a lesser extent, this also holds for Bacillus thuringiensis israelensis (Bti), the most widely used biological pesticide to control mosquito populations. This raises the need for the development of integrated pest management strategies that allow ...

Evolution determines how global warming and pesticide exposure will shape predator-prey interactions with vector mosquitoes KU Leuven

Thanh Tam Tran, Lizanne Janssens, Khuong Dinh Van, Lin Op de Beeck, Robby Stoks
How evolution may mitigate the effects of global warming and pesticide exposure on predator-prey interactions is directly relevant for vector control. Using a space-for-time substitution approach we addressed how 4°C warming and exposure to the pesticide endosulfan shape the predation on Culex pipiens mosquitoes by damselfly predators from replicated low- and high-latitude populations. Although warming was only lethal for themosquitoes, it ...

NO BUG: biobased mosquitoes repellent personal protective equipment (PPE) Universiteit Gent

Lucy Wanjiru Ciera, Vincent Nierstrasz, Lieva Van Langenhove
In tropical regions (South America, Asia and Africa) diseases like malaria and dengue cause many deaths. These diseases are transmitted through mosquitoes bites (Anopheles sp. and Aedes aegypti respectively). The current practice to protect against transmission of these diseases is by use of mosquito repellents. Common mosquito repellents used today are synthetic in nature and are suspected or have been proved to be harmful to the user and ...

An entomological review of invasive mosquitoes in Europe

J M Medlock, K M Hansford, V Versteirt, B Cull, H Kampen, D Fontenille, G Hendrickx, H Zeller, Wim Van Bortel, F Schaffner, et al.

Among the invasive mosquitoes registered all over the world, Aedes species are particularly frequent and important. As several of them are potential vectors of disease, they present significant health concerns for 21st century Europe. Five species have established in mainland Europe, with two (Aedes albopictus and Aedes japonicus) becoming widespread and two (Ae. albopictus and Aedes aegypti) implicated in disease transmission to humans in ...