Projecten
Focus op het bevorderen van ruimtelijke en temporele resolutie van 3D-gestructureerde verlichtingsmicroscopie KU Leuven
Super-resolved structured illumination microscopy (SR-SIM) is an important method to surpass the resolution limit in fluorescence microscopy. SR-SIM is compatible with many fluorescent labels and ensures low photo-damage, making it an ideal candidate for live-cell imaging. However, to be truly applicable, very fast 3D imaging has to be realized, as the cellular structuring is 3D in nature and fast dynamics have to be captured. In addition, ...
Bidirectionele krachtcommunicatie op celmatrix KU Leuven
Cells continuously sense external forces from their microenvironment, the extracellular matrix (ECM). In turn, they generate contractile forces, which stiffen and remodel this matrix. Although this bi-directional mechanical exchange is crucial for many cell functions, is remains poorly understood, mostly since the majority of ECMs, both natural and synthetic, are difficult to control or lack biological relevance. A new synthetic ...
Moleculaire gegevensopslag van de volgende generatie KU Leuven
Current long-term archival media (such as tape and disk) have several issues, the most important one being that they are short lived (up to 5-10 years) forcing data to be copied between storage media every few years in a costly process which also produces considerable electronic waste.
Longer-lasting media are desperately needed and DNA oligos have been identified as a major contender to be the next archival storage medium. With ...
Fluorescentiebeeldvorming van de volgende generatie voor onderzoek en theranostiek KU Leuven
Fluorescence microscopy is key technique in the life sciences, though the method struggles to deliver the fast and sensitive imaging of multicellular systems. Such samples are now becoming commonplace not only in research but also in clinical use, including spatially-resolved 'omics' and theranostics based on patient material that allow the development of personalized treatments. However, their general uptake is limited by the absence of ...
Immuunmechanismen van necrotisch DNA Fagocytose door neutrofielen: een rol voor integrinen KU Leuven
Cell death is inherently connected to the existence of multicellular organisms. Our body loses billions of cells a day due to thermal, mechanical or chemical damage in a cell death process with loss of plasma membrane integrity and pro-inflammatory properties known as necrosis. Organisms face necrosis frequently, thus, there must be specific pathways to remove the large amount of cellular debris left behind. In this way, it is no surprise ...
Nanometerschaalafbeelding van magnetische perovskietoxide dunne films met behulp van scanning transmissie-elektronenmicroscopie (MAGIMOX). Universiteit Antwerpen
2D3DSCOPY Universiteit Gent
Efficiënt gebruik van grondstoffen vereist een combinatie van nauwkeurige analytische gegevens en betrouwbare simulatiesoftware. Dit maakt de betrouwbare voorspelling van terugwinning van waardevolle componenten mogelijk, evenals de karakterisering van residuen die worden gegenereerd tijdens minerale verwerking en metallurgische extractie. In dit project ontwikkelen we een service en gelicentieerde software die kwantitatieve tweedimensionale ...
Synthese en karakterisatie van 2D geconjugeerde organische polymeren: een elektrochemische benadering. KU Leuven
MOF- en COF-hybride ultradunne films: een nanolithografie-benadering met oppervlaktesjablonen en scanning-sondes KU Leuven
Single organic molecules can be joined together to form extended frameworks. Materials that use metal-ligand coordination or direct covalent bonding as the ‘glue’ between organic subunits, termed metal-organic frameworks
(MOFs) and covalent organic frameworks (COFs), respectively, are being developed for a huge variety of applications.
Hybrid materials, containing two, or in some cases more, distinct types of MOF and COF often have ...