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Low Genetic Connectivity of Strongly Inbred Ruppia brevipedunculata in Aquaculture Dominated Lagoons (Viet Nam) Vrije Universiteit Brussel

Ludwig Triest, Jasper Dierick, Phan Thi Thuy Hang, Quang Doc Luong, Quang Huy Nguyen, Timothy Sierens

Lagoonal environments exhibit high levels of instability depending on hydrological, climatic and ecological factors, thereby influencing the distribution and structure of submerged plant communities. Conditions typically fluctuate widely due to the interaction of freshwater from rivers with saltwater from the sea, as well as from aquaculture activities that together influence submerged hydrophyte community spatial and temporal variability ...

Temporal drop of genetic diversity in Bombus pauloensis Universiteit Gent

Kevin Maebe, Marina Haramboure, Mariano Lucia, Lepoldo Jésus Alvarez, Guy Smagghe
Bumblebees are economically important insects which perform essential pollination tasks in natural and managed ecosystems. Recent research studying Neotropical bumblebee species in Brazil showed a clear decrease in genetic diversity over time in Bombus pauloensis. A new temporal assessment of genetic diversity is needed to know whether this was a location-specific result, or a more general phenomenon. This knowledge is essential to be able to ...

Isotropic and anisotropic processes influence fine-scale spatial genetic structure of a keystone tropical plant Vrije Universiteit Brussel

Addisie Yalew Geremew, Melkamu Woldemariam, Alemayehu Kefalew, Iris Stiers, Ludwig Triest

Limited seed or pollen dispersal enhances spatial genetic relatedness between individuals (fine-scale spatial genetic structure, FSGS), which usually decreases as a function of physical distance. However, such isotropic pattern of FSGS may not always occur when spatially asymmetric processes, for instance, wind direction during dispersal, are considered in wind-pollinated and -dispersed plants. This study assessed the pattern of FSGS in the ...

Bidirectional gene flow on a mangrove river landscape and between-catchment dispersal of Rhizophora racemosa (Rhizophoraceae) Vrije Universiteit Brussel KU Leuven

Magdalene Ngeve, Tom Van der Stocken, Timothy Sierens, Nico Koedam, Ludwig Triest

Understanding how landscape structure shapes the genetic structure of populations of keystone species is important for their long-term management. We tested the unidirectional dispersal hypothesis on the linear river landscape of the Wouri River and the one catchment-one gene pool hypothesis on red mangrove (Rhizophora racemosa) populations of the Cameroon Estuary complex. Therefore, we conducted release–recapture experiments in the field, ...

Genetic ablation of phospholipase C delta 1 increases survival in SOD1(G93A) mice KU Leuven

Kim Staats, Lawrence Van Helleputte, Robin Lemmens, Philip Van Damme, Adrian Liston, Wim Robberecht, Ludo Van Den Bosch
Amyotrophic Lateral Sclerosis (ALS) is a devastating progressive neurodegenerative disease, resulting in selective motor neuron degeneration and paralysis. Patients die approximately 3-5years after diagnosis. Disease pathophysiology is multifactorial, including excitotoxicity, but is not yet fully understood. Genetic analysis has proven fruitful in the past to further understand genes modulating the disease and increase knowledge of disease ...

A resource of genome-wide single-nucleotide polymorphisms generated by RAD tag sequencing in the critically endangered European eel KU Leuven

Gregory Maes
increased use to identify and genotype large numbers of single-nucleotide polymorphisms (SNPs) in model and nonmodel species. We generated a unique resource of novel SNP markers for the European eel using the RAD sequencing approach that was simultaneously identified and scored in a genome-wide scan of 30 individuals. Whereas genomic resources are increasingly becoming available for this species, including the recent release of a draft genome, ...

Molecular surveillance of Plasmodium falciparum drug-resistance markers in Vietnam using multiplex amplicon sequencing (2000-2016) Instituut voor Tropische Geneeskunde

Eduard Rovira Vallbona, Eline Kattenberg, Nguyen Van Hong, Pieter Guetens, Hideo Imamura, Pieter Monsieurs, Driss Chiheb, Annette Erhart, Bui Quang Phuc, Nguyen Xuan Xa, et al.

Emergence and spread of Plasmodium falciparum resistance to artemisinin-based combination therapies (ACT) is a major challenge for Greater Mekong Subregion countries in their goal to eliminate malaria by 2030. Tools to efficiently monitor drug resistance beyond resource-demanding therapeutic efficacy studies are necessary. A custom multiplex amplicon sequencing assay based on Illumina technology was designed to target the marker of partial ...

Population genomics and trophic ecology of polar cod (Boreogadus saida) in a changing Arctic Ocean KU Leuven

Sarah Maes
Temperatures in the Arctic are rising three times faster than the global average, resulting in a rapid decline in sea-ice, and lengthening of the ice-free season. As sea ice retreats, fishing grounds that were previously not accessible will inevitable open up and shipping activities in the Arctic will increase together with the potential of accidental oil spills into the marine ecosystem. Environmental changes, together with increased ...

Mismatch repair deficiency is rare in bone and soft tissue tumors KU Leuven

Patrick Schöffski, Jerry Lee
INTRODUCTION: There has been an increased demand for mismatch repair (MMR) status testing in sarcoma patients after the success of immune checkpoint inhibition (ICI) in MMR deficient tumors. However, data on MMR deficiency in bone and soft tissue tumors is sparse, rendering it unclear if routine screening should be applied. Hence, we aimed to study the frequency of MMR deficiency in bone and soft tissue tumors after we were prompted by two ...

Expansion of the mangrove species Rhizophora mucronata in the Western Indian Ocean launched contrasting genetic patterns Vrije Universiteit Brussel

Ludwig Triest, Tom Van der Stocken, Dennis De Ryck, Marc Kochzius, Sophie Anaïs Lorent, Magdalene Ngeve, Hajaniaina A. Ratsimbazafy, Tim Sierens, Rosa Van Der Ven, Nico Koedam, et al.

Estimates of population structure and gene flow allow exploring the historical and contemporary processes that determine a species' biogeographic pattern. In mangroves, large-scale genetic studies to estimate gene flow have been conducted predominantly in the Indo-Pacific and Atlantic region. Here we examine the genetic diversity and connectivity of Rhizophora mucronata across a > 3,000 km coastal stretch in the Western Indian Ocean (WIO) ...