Publicaties
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Endothelial cell metabolism: parallels and divergences with cancer cell metabolism KU Leuven
The stromal vasculature in tumors is a vital conduit of nutrients and oxygen for cancer cells. To date, the vast majority of studies have focused on unraveling the genetic basis of vessel sprouting (also termed angiogenesis). In contrast to the widely studied changes in cancer cell metabolism, insight in the metabolic regulation of angiogenesis is only just emerging. These studies show that metabolic pathways in endothelial cells (ECs) ...
Hepatocyte MyD88 affects bile acids, gut microbiota and metabolome contributing to regulate glucose and lipid metabolism KU Leuven
OBJECTIVE: To examine the role of hepatocyte myeloid differentiation primary-response gene 88 (MyD88) on glucose and lipid metabolism. DESIGN: To study the impact of the innate immune system at the level of the hepatocyte and metabolism, we generated mice harbouring hepatocyte-specific deletion of MyD88. We investigated the impact of the deletion on metabolism by feeding mice with a normal control diet or a high-fat diet for 8 weeks. We ...
In vitro microbial metabolism of (+)-catechin reveals fast and slow converters with individual-specific microbial and metabolite markers Universiteit Gent
Proteomic and Low-Polar Metabolite Profiling Reveal Unique Dynamics in Fatty Acid Metabolism during Flower and Berry Development of Table Grapes KU Leuven
Grapevine development and ripening are complex processes that involve several biochemical pathways, including fatty acid and lipid metabolism. Fatty acids are essential components of lipids, which play crucial roles in fruit maturation and flavor development. However, the dynamics of fatty acid metabolism in grape flowers and berries are poorly understood. In this study, we present those dynamics and investigate the mechanisms of fatty acid ...
GBM tumors are heterogeneous in their fatty acid metabolism and modulating fatty acid metabolism sensitizes cancer cells derived from recurring GBM tumors to temozolomide. Vlaams Instituut voor Biotechnologie KU Leuven Vrije Universiteit Brussel
Priming with gamma-Aminobutyric Acid against Botrytis cinerea Reshuffles Metabolism and Reactive Oxygen Species: Dissecting Signalling and Metabolism KU Leuven
The stress-inducible non-proteinogenic amino acid γ-aminobutyric acid (GABA) is known to alleviate several (a)biotic stresses in plants. GABA forms an important link between carbon and nitrogen metabolism and has been proposed as a signalling molecule in plants. Here, we set out to establish GABA as a priming compound against Botrytis cinerea in Arabidopsis thaliana and how metabolism and reactive oxygen species (ROS) are influenced after GABA ...
Impairment of gut microbial biotin metabolism and host biotin status in severe obesity: effect of biotin and prebiotic supplementation on improved metabolism. Vlaams Instituut voor Biotechnologie KU Leuven
An emerging role for Torsins in Lipid metabolism and NPC biogenesis - The NEP1R1-CTDNEP1/ Lipin pathway regulates PA metabolism for a broad set of cellular events KU Leuven
My project seeks for a further understanding of the neurological movement disorder dystonia in order to provide new therapeutic targets for this incurable type of disease. This neurological disease is the third most common movement disorder and is characterized by abnormal, involuntary muscle contractions that cause twisting movements and force the body into sustained, abnormal postures. Dystonia is a chronical and incurable disease that has a ...