Publicaties
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Long-term instability of the intestinal microbiome is associated with metabolic liver disease, low microbiota diversity, diabetes mellitus and impaired exocrine pancreatic function. KU Leuven
OBJECTIVE: The intestinal microbiome affects the prevalence and pathophysiology of a variety of diseases ranging from inflammation to cancer. A reduced taxonomic or functional diversity of the microbiome was often observed in association with poorer health outcomes or disease in general. Conversely, factors or manifest diseases that determine the long-term stability or instability of the microbiome are largely unknown. We aimed to identify ...
Influence of Live Attenuated Salmonella Vaccines on Cecal Microbiome Composition and Microbiota Abundances in Young Broiler Chickens KU Leuven
Salmonellosis is a global food safety challenge caused by Salmonella, a gram-negative bacterium of zoonotic importance. Poultry is considered a major reservoir for the pathogen, and humans are exposed through consumption of raw or undercooked products derived from them. Prophylaxis of Salmonella in poultry farms generally mainly involves biosecurity measures, flock testing and culling, use of antibiotics, and vaccination programs. For decades, ...
Dissecting the role of the gut microbiome and fecal microbiota transplantation in radio- and immunotherapy treatment of colorectal cancer Universiteit Antwerpen
Colorectal cancer (CRC) is one of the most commonly diagnosed cancers and poses a major burden on the human health worldwide. At the moment, treatment of CRC consists of surgery in combination with (neo)adjuvant chemotherapy and/or radiotherapy. More recently, immune checkpoint blockers (ICBs) have also been approved for CRC treatment. In addition, recent studies have shown that radiotherapy and ICBs act synergistically, with radiotherapy ...
Standardization of Plant Microbiome Studies: Which Proportion of the Microbiota is Really Harvested? Vlaams Instituut voor Biotechnologie Universiteit Gent
Quantitative microbiome profiling disentangles inflammation- and bile duct obstruction-associated microbiota alterations across PSC/IBD diagnoses. Vlaams Instituut voor Biotechnologie KU Leuven
Models of the human microbiota and microbiome in vitro Universiteit Gent
Identificatie van covarianten van het menselijk darm microbioom. KU Leuven
SummaryMore than eighty years after the isolation of the first gastrointestinal bacterium in 1885, research on the microbes inside our body finally took off. Since then, improvements in culturing techniques paved the way for the exploration of the complex microbial community inside our guts. In the last decades, the rapid development of sequencing approaches, allowing the identification of our microbial companions based on their DNA, has speeded ...
Aanpak van de draaglast van respiratoire virussen - Epidemiologie en classificatie van humaan respiratoir syncytieel virus & Analyse van het respiratoir microbioom KU Leuven
My PhD project consists of 2 parts: Epidemiology of hRSV on one hand and Virome analysis of the respiratory tract on the other hand. In the first part "Epidemiology of hRSV" the circulation of hRSV in Belgium will be studied. Every child experiences during the first 5 years at least one hRSV infection. In some cases this leads to serious complications which result in hospital submission. In the context of prevention it is important to gain more ...