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Long-term antibody persistence after vaccination with a 2-dose Havrix (TM) (inactivated hepatitis A vaccine): 20 years of observed data, and long-term model-based predictions Universiteit Hasselt Universiteit Antwerpen Universiteit Gent

Heidi Theeten, Koen Van Herck, Olivier Van Der Meeren, Priya Crasta, Pierre Van Damme, Niel HENS
Antibody persistence in two cohorts of adults, who received inactivated hepatitis A (HAV) vaccine (1440El.U; Havrix (TM); GSK Vaccines) according to a 0-6 or 0-12 month schedule in 1992-1993, has been measured annually. After 20 years, >97% of the subjects in both studies were seropositive for anti-HAV antibodies. Geometric mean concentrations in the according-to-protocol cohorts were 312 mIU/ml in 34/36 subjects vaccinated initially at 0-6 ...

Long-term safety and efficacy of filgotinib for the treatment of moderately to severely active ulcerative colitis: Interim analysis from up to 4 years of follow-up in the SELECTION open-label long-term extension study KU Leuven

Séverine Vermeire
BACKGROUND: Filgotinib, an oral, once-daily, Janus kinase 1 preferential inhibitor, is an approved treatment for moderately to severely active ulcerative colitis. AIMS: The aim of this study is to assess the safety and efficacy of continued filgotinib therapy over ~4 years in the long-term extension of the phase 2b/3 SELECTION trial (SELECTIONLTE; NCT02914535). METHODS: In this interim analysis of SELECTIONLTE, SELECTION completers (week 10 ...

Side Effects from Cancer Therapies and Perspective of 1044 Long-Term Ovarian Cancer Survivors-Results of Expression VI-Carolin Meets HANNA-Holistic Analysis of Long-Term Survival with Ovarian Cancer: The International NOGGO, ENGOT, and GCIG Survey KU Leuven

Ignace Vergote
The aim of this survey was to increase the knowledge on the characteristics and health concerns of long-term survivors (LTS; survival > 5 years) after ovarian cancer in order to tailor follow-up care. This international survey was initiated by the NOGGO and was made available to members of ENGOT and GCIG. The survey is anonymous and consists of 68 questions regarding sociodemographic, medical (cancer) history, health concerns including ...

The long-term effect of vagus nerve stimulation on quality of life in patients with pharmcoresitant focal epilepsy: the PuLse (Open Prospective Randomized Long-term Effectiveness) trial Universiteit Gent

Philippe Ryvlin, Frank G Gilliam, Dang K Nguyen, Gabriella Colicchio, Alfonso Iudice, Paolo Tinuper, Nelia Zamponi, Umberto Aguglia, Louis Wagner, Lorella Minotti, et al.
Objective: To evaluate whether vagus nerve stimulation (VNS) as adjunct to best medical practice (VNS+BMP) is superior to BMPalone in improving long-term health-related quality of life (HRQoL). Methods: PuLsE (Open Prospective Randomized Long-term Effectiveness) was a prospective, randomized, parallel-group, open-label, and long-term effectiveness study (conducted at 28sites in Europe and Canada). Adults with pharmacoresistant focal seizures ...

Hyponatraemia and changes in natraemia during hospitalization for acute heart failure and associations with in-hospital and long-term outcomes - from the ESC-HFA EORP Heart Failure Long-Term Registry Universiteit Hasselt

Agnieszka Kaplon-Cieslicka, Lina Benson, Ovidiu G. Chioncel, Maria Crespo-Leiro, Andrew J. S. D. Coats, Stefan Anker, Frank Ruschitzka, Camilla Hage, Jaroslaw Drozdz, Petar Seferovic, et al.
Aims To comprehensively assess hyponatraemia in acute heart failure (AHF) regarding prevalence, associations, hospital course, and post-discharge outcomes. Methods and results Of 8298 patients in the European Society of Cardiology Heart Failure Long-Term Registry hospitalized for AHF with any ejection fraction, 20% presented with hyponatraemia (serum sodium <135 mmol/L). Independent predictors included lower systolic blood pressure, estimated ...

A Combined Prospective and Retrospective Comparison of Long-Term Functional Outcomes Suggests Delayed Loss of Ambulation and Pulmonary Decline with Long-Term Eteplirsen Treatment KU Leuven

Nathalie Goemans
BACKGROUND: Studies 4658-201/202 (201/202) evaluated treatment effects of eteplirsen over 4 years in patients with Duchenne muscular dystrophy and confirmed exon-51 amenable genetic mutations. Chart review Study 4658-405 (405) further followed these patients while receiving eteplirsen during usual clinical care. OBJECTIVE: To compare long-term clinical outcomes of eteplirsen-treated patients from Studies 201/202/405 with those of external ...

Long-term follow-up of the red density pilot trial: a basis for long-term prediction of sustained clinical remission in ulcerative colitis? KU Leuven

Pieter Sinonquel, Peter Bossuyt, João Guedelha Sabino, Bram Verstockt, Séverine Vermeire, Raf Bisschops
Red density (RD) technology is an automated operator-independent endoscopic scoring system for disease activity in ulcerative colitis (UC). In this retrospective analysis we aimed to assess the predictive value of the RD sore for sustained clinical remission. All 39 patients from the RD pilot trial were evaluated for clinical outcome in a 5-year period. The highest RD score was considered for Receiver operating characteristic (ROC) analysis to ...

Gini's mean difference and the long-term prognostic value of nodal quanta classes after pre-operative chemotherapy in advanced breast cancer Vrije Universiteit Brussel

Vincent Vinh - Hung, Hilde Van Parijs, Olena Gorobets, Christel Fontaine, Nam P Nguyen, Bhumsuk Keam, Dung Minh Nguyen, Mark De Ridder

Gini's mean difference (GMD, mean absolute difference between any two distinct quantities) of the restricted mean survival times (RMSTs, expectation of life at a given time limit) has been proposed as a new metric where higher GMD indicates better prognostic value. GMD is applied to the RMSTs at 25 years time-horizon to evaluate the long-term overall survival of women with breast cancer who received neoadjuvant chemotherapy, comparing a ...