Dysregulation of Microtubule Stability Impairs Morphofunctional Connectivity in Primary Neuronal Networks Universiteit Hasselt Universiteit Gent Universiteit Antwerpen
Functionally related neurons assemble into connected networks that process and transmit electrochemical information. To do this in a coordinated manner, the number and strength of synaptic connections is tightly regulated. Synapse function relies on the microtubule (MT) cytoskeleton, the dynamics of which are in turn controlled by a plethora of MT-associated proteins, including the MT-stabilizing protein Tau. Although mutations in the ...