Deficient lysosomal polyamine export is at the heart of ATP13A2-associated neurodegeneration KU Leuven
ATP13A2/PARK9 encodes a ubiquitously expressed late endo-/lysosomal orphan transporter that is implicated in a spectrum of neurodegenerative disorders, including Kufor-Rakeb syndrome and Parkinson's disease. ATP13A2 plays a neuroprotective role, since its loss leads to compromised lysosomal function, impaired autophagy and mitochondrial fragmentation. Furthermore, ATP13A2 offers protection to α-synuclein, the major aggregated protein in brain ...