Publicaties
Co-transmission of conduct problems with attention-deficit/hyperactivity disorder: familial evidence for a distinct disorder Universiteit Gent
Reactive, self-administered malaria treatment against asymptomatic malaria infection: results of a cluster randomized controlled trial in The Gambia Instituut voor Tropische Geneeskunde
BACKGROUND: Selectively targeting and treating malaria-infected individuals may further decrease parasite carriage in low-burden settings. Using a trans-disciplinary approach, a reactive treatment strategy to reduce Plasmodium falciparum prevalence in participating communities was co-developed and tested.
METHODS: This is a 2-arm, open-label, cluster-randomized trial involving villages in Central Gambia during the 2017 and 2018 ...
Identification and characterization of areas of high and low risk for asymptomatic malaria infections at sub-village level in Ratanakiri, Cambodia Instituut voor Tropische Geneeskunde Universiteit Antwerpen
Background: Malaria elimination needs a concentration of activities towards identification of residual transmission foci and intensification of efforts to eliminate the last few infections, located in so-called 'malaria hotspots'. Previous work on characterizing malaria transmission hotspots has mainly focused on falciparum malaria and especially on symptomatic cases, while the malaria reservoir is expected to be mainly concentrated in the ...
Mass drug administration with dihydroartemisinin-piperaquine and malaria transmission dynamics in The Gambia: a prospective cohort study Instituut voor Tropische Geneeskunde Vrije Universiteit Brussel Universiteit Antwerpen
BACKGROUND: Mass drug administration (MDA) may further reduce malaria transmission in low-transmission areas. The impact of MDA on the dynamics of malaria transmission was determined in a prospective cohort study.
METHODS: Annual rounds of MDA with dihydroartemisinin-piperaquine (DP) were implemented were implemented in 2014 and 2015 in six village pairs before the malaria transmission season. Blood samples were collected from ...
Infectivity of patent Plasmodium falciparum gametocyte carriers to mosquitoes Universiteit Antwerpen
Reactive community-based self-administered treatment against residual malaria transmission: study protocol for a randomized controlled trial Instituut voor Tropische Geneeskunde
Background: Systematic treatment of all individuals living in the same compound of a clinical malaria case may clear asymptomatic infections and possibly reduce malaria transmission, where this is focal. High and sustained coverage is extremely important and requires active community engagement. This study explores a community-based approach to treating malaria case contacts.
Methods/design: This is a cluster-randomized trial to ...
Additional screening and treatment of malaria during pregnancy provides further protection against malaria and nonmalarial fevers during the first year of life Instituut voor Tropische Geneeskunde Universiteit Antwerpen
Background: Although consensus exists that malaria in pregnancy (MiP) increases the risk of malaria in infancy, and eventually nonmalarial fevers (NMFs), there is a lack of conclusive evidence of benefits of MiP preventive strategies in infants.
Methods: In Burkina Faso, a birth cohort study was nested to a clinical trial assessing the effectiveness of a community-based scheduled screening and treatment of malaria in combination with ...
Implementation and application of a multiplex assay to detect malaria-specific antibodies Instituut voor Tropische Geneeskunde Universiteit Antwerpen
BACKGROUND: Epidemiological surveillance is a key activity in malaria control and elimination in low-transmission and pre-elimination settings. Hence, sensitive tools for estimating malaria force of infection are crucial. Serological markers might provide additional information in estimating force of infection in low-endemic areas along with classical parasite detection methods. Serological markers can be used to estimate recent, past or ...