Aneuploidy and mosaicism: a strategy for early adaptation todrug pressure in Leishmania Instituut voor Tropische Geneeskunde
Unlike higher eukaryotes, Leishmania, a unicellular protozoan parasite, not only tolerates high levels of aneuploidy, but also exploits it for rapid adaptation to environmental changes, by altering gene copy number and consequently modulating the abundance of key proteins. In particular, aneuploidy constitutes the very first genomic modification during in vitro experimental selection of drug resistance. It is unclear how Leishmania cell ...