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Interleukin-1 alpha induced release of interleukin-8 by human bronchial epithelial cells in vitro Universiteit Antwerpen KU Leuven
Survival after lung transplantation is hampered by chronic lung allograft dysfunction (CLAD). Persistently elevated BAL-neutrophilia is observed in some patients despite treatment with azithromycin, which may be induced by IL-1 alpha. Our aim is to establish an in vitro model, assess mechanistic pathways and test different therapeutic strategies of IL-1 alpha-induced release of IL-8 by human bronchial epithelial cells. Bronchial epithelial cells ...
Marked independent relationship between circulating interleukin-6 concentrations and endothelial activation in rheumatoid arthritis Vrije Universiteit Brussel
We examined the potential impact of conventional compared with nonconventional cardiovascular risk factors including interleukin-6 levels on endothelial activation in RA. Circulating soluble E-selectin, vascular cell adhesion molecule-1, intercellular adhesion molecule-1, and monocyte chemoattractant protein-1 concentrations were measured in 217 African patients (112 black and 105 white) with RA. In comprehensive confounder adjusted mixed ...
The role of interleukin-6 in pulmonary and systemic manifestations in a murine model of chronic obstructive pulmonary disease Universiteit Gent
Interleukin-6, a mental cytokine Universiteit Gent
Mendelian randomization study of interleukin-6 in chronic obstructive pulmonary disease Universiteit Gent
Interleukin-6 dynamics as a basis for an early-warning monitor for sepsis and inflammation in individual pigs KU Leuven Universiteit Gent
Static interleukin-6 (IL-6) levels of pigs contain considerable individual differences, which obstruct the practical use of IL-6 for disease monitoring purposes. It was hypothesised that interleukin-6 (IL-6) dynamics could be used to quantify these individual differences and carries critical information of the individual pig infection status. Time series of IL-6 responses in 25 pigs were analysed before and after infection by Actinobacillus ...
Hyperactivated NF-κB and AP-1 transcription factors promote highly accessible chromatin and constitutive transcription across the interleukin-6 gene promoter in metastatic breast cancer cells Universiteit Gent Universiteit Antwerpen
Interleukin-6 (IL-6), involved in cancer-related inflammation, acts as an autocrine and paracrine growth factor, which promotes angiogenesis, metastasis, and subversion of immunity, and changes the response to hormones and to chemotherapeutics. We explored transcription mechanisms involved in differential IL-6 gene expression in breast cancer cells with different metastatic properties. In weakly metastatic MCF7 cells, histone H3 K9 methylation, ...