The Use of Comparative Genomic Hybridization and Fluorescent In Situ Hybridization in Postmortem Pathology Investigation of Congenital Malformations KU Leuven
Chromosomal abnormalities are an important cause of multiple congenital anomalies (MCA). However, conventional cytogenetic analysis using culture is unsuccessful in 10% to 40% of the cases. The purpose of this study was to examine if retrospective chromosomal analysis was possible on paraffin-embedded autopsy material with new techniques, including comparative genomic hybridization (CGH) and fluorescent in situ hybridization (FISH). We ...