Publicaties
Gekozen filters:
Gekozen filters:
Engraftment versus immunosuppression Vrije Universiteit Brussel
OBJECTIVE: Immunosuppression (IS) in islet transplantation (Tx) is a double-edged sword: it prevents immunoreaction but has the potential to impair islet engraftment. The aim of this study was to identify in murine animal models the IS platform with the best balance between these two opposite effects.
METHODS: To study the impact of IS on islet engraftment diabetic C57BL/6 mice were transplanted with 350 syngeneic islets through the ...
ImmunoStart: preparing patients for immunosuppression Universiteit Hasselt
Objectives. Patients with immune-mediated inflammatory disease (IMID) present an increased risk of infection. Here, we present the concept of a preventive consultation called ImmunoStart and the first results of its implementation in the care pathway of patients with IMID. Methods. Relevant information about vaccination history, tuberculosis exposure and other infectious risks were collected through blood sampling, complete anamnesis, chest ...
Immune responses against islet allografts during tapering of immunosuppression - a pilot study in 5 subjects Vrije Universiteit Brussel
Transplantation of isolated islet of Langerhans cells has great potential as a
cure for type 1 diabetes but continuous immune suppressive therapy often
causes considerable side effects. Tapering of immunosuppression in successfully
transplanted patients would lower patients' health risk. To identify
immune biomarkers that may prove informative in monitoring tapering, we
studied the effect of tapering on islet auto- ...
cure for type 1 diabetes but continuous immune suppressive therapy often
causes considerable side effects. Tapering of immunosuppression in successfully
transplanted patients would lower patients' health risk. To identify
immune biomarkers that may prove informative in monitoring tapering, we
studied the effect of tapering on islet auto- ...
Mycobacterium ulcerans triggers T cell immunity followed by local and regional but not systemic immunosuppression Instituut voor Tropische Geneeskunde
Buruli ulcer (BU) is a neglected infectious disease caused by Mycobacterium ulcerans, characterized by necrotic cutaneous lesions induced by the exotoxin mycolactone. Despite evidence of Th1-mediated protective immunity, M. ulcerans infection has been associated with systemic immunosuppression. We show that early during mouse infection with either mycolactone-positive or negative strains, pathogen-specific IFN-gamma-producing T cells developed ...
The relationship of Plasmodium falciparum humeral immunity with HIV-1 immunosuppression and treatment efficacy in Zambia Instituut voor Tropische Geneeskunde
Immunosuppression of experimental autoimmune myasthenia gravis by mycophenolate mofetil Universiteit Hasselt
Currently used non-specific immunosuppresive drugs often require intervention in myasthenia gravis (MG) and clinical improvement varies widely. To analyze the therapeutic effect of mycophenolate mofetil (MMF) in experimental autoimmune MG (EAMG), rats were immunized with acetylcholine receptors (AChRs) and subsequently treated with MMF or vehicle. MMF treatment resulted in a significant suppression of anti-rat AChR antibody titers. ...
The associations between cervicovaginal HIV shedding, sexually transmitted diseases and immunosuppression in female sex workers in Abidjan, Côte d'Ivoire Instituut voor Tropische Geneeskunde
Experimental brucei trypanosomiasis: immunosuppression of the blood-aqueous barrier Instituut voor Tropische Geneeskunde
Rationale and design of the OPTIMIZE trial: OPen label multicenter randomized trial comparing standard IMmunosuppression with tacrolimus and mycophenolate mofetil with a low exposure tacrolimus regimen In combination with everolimus in de novo rena KU Leuven
BACKGROUND: In 2019, more than 30 % of all newly transplanted kidney transplant recipients in The Netherlands were above 65 years of age. Elderly patients are less prone to rejection, and death censored graft loss is less frequent compared to younger recipients. Elderly recipients do have increased rates of malignancy and infection-related mortality. Poor kidney transplant function in elderly recipients may be related to both pre-existing (i.e. ...