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mRNA electroporation as a tool for immunomonitoring Universiteit Antwerpen
Efficient mRNA electroporation of peripheral blood mononuclear cells to detect memory T cell responses for immunomonitoring purposes Universiteit Antwerpen
To date, the number of immunotherapy vaccines in clinical trials increases exponentially. To evaluate the efficacy of these clinical vaccination trials, we fervently need cellular immunomonitoring tools. In this study, we present a newly developed short-time assay which allows direct ex vivo analysis of multi-epitope antigen-specific T cell immune responses. This novel method is based on mRNA electroporation of isolated peripheral blood ...
Macrophage Differentiation and Activiation States in the Tumor Microenvironment Vrije Universiteit Brussel
Interaction between malignant cells and their surrounding tissue plays a crucial role in tumor growth, invasiveness and spreading to the distant organs. New findings provide evidence of a principal importance of the immune cells for controlling this interaction and orchestrating multiple events in the tumor microenvironment. The balance between immune cells that support tumor progression and immune cells that sustain tumor-controlling immune ...