The clinical value of assays detecting antibodies against domain I of β2-glycoprotein I in the antiphospholipid syndrome Universiteit Gent
As the clinical symptoms of the antiphospholipid syndrome (APS) frequently occur irrespective of the syndrome, diagnosis predominantly depends on the laboratory assays measuring the level or function of antiphospholipid antibodies (aPLs). beta 2-glycoprotein I (beta 2GPI) is increasingly accepted as the most important target of aPLs. Anti-beta 2GPI antibodies constitute a heterogeneous population, but current in vivo and in vitro evidence show ...