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Korte historiek van het aandeel van de diergeneeskunde in het experimenteel onderzoek in de humane geneeskunde = A short description of veterinary contributions to experimental research in human medicine Universiteit Gent

J. Bouckaert, Luc Devriese
A short description is given of the life and work of scientists active in veterinary research, who contributed substantially to the knowledge of human disease and health. Microbiology and immunology were their main fields of interest. Important microbiologists include Edmond Nocard, Karl F. Meyer, Daniel Salmon, Victor Babes and Arnold Theiler. Still others were mainly active as immunologists. Gaston Ramon's works on bacterial toxins resulted in ...

Human filariasis in travelers and migrants: a retrospective 25-year analysis at the Institute of Tropical Medicine, Antwerp, Belgium Instituut voor Tropische Geneeskunde

Emmanuel Bottieau, Ralph Huits, Steven Van Den Broucke, Ula Maniewski-Kelner, Steven Declercq, Isabel Brosius, Caroline Theunissen, Anne-Marie Feyens, Marjan Van Esbroeck, Johan van Griensven, et al.

BACKGROUND: Information on human filariasis in international travelers is scarce. We describe the epidemiology, clinical presentation, and outcome of these infections in a reference travel clinic over the past decades.

METHODS: We reviewed all cases of filariasis diagnosed at the Institute of Tropical Medicine, Antwerp, Belgium, from 1994 to 2018. Diagnosis was obtained by either parasitological methods (confirmed) or strict clinical ...

Optimizing the European Regulatory Framework for Sustainable Bacteriophage Therapy in Human Medicine Vrije Universiteit Brussel

Gilbert Verbeken, Jean-Paul Pirnay, D. De Vos, S. Jennes, Martin Zizi, R. Lavigne, Minne Casteels
For practitioners at hospitals seeking to use natural (not genetically modified, as appearing in nature) bacteriophages for treatment of antibiotic-resistant bacterial infections (bacteriophage therapy), Europe's current regulatory framework for medicinal products hinders more than it facilitates. Although many experts consider bacteriophage therapy to be a promising complementary (or alternative) treatment to antibiotic therapy, no ...

DSD : a discussion at the crossroads of medicine, human rights, and politics Universiteit Gent

Petra De Sutter
Over the past years, the topic of "disorder/differences in sex development (DSD)" or "intersex" people has become subject of the international political agenda. In 2017, a resolution of the Parliamentary Assembly of the Council of Europe argued that the practice of surgically modifying intersex children's genitals without medical necessity and without consent of the person concerned is a human rights violation. This resolution and related ...

Laterality in modern medicine : a historical overview of animal laterality, human laterality, and current influences in clinical practice Universiteit Gent

Frank W. de Jongh, Sjaak Pouwels, Zoe E. Kooreman, Elijah E. Sanches, Emily Aupers, Dharmanand Ramnarain, Carien H. G. Beurskens, Stan Monstrey, Ietske Siemann, Nicol C. Voermans, et al.
K.C. Garrison was the first to define laterality. Later on, this definition was widely accepted and is as follows: "preference in the use of homologous parts on one lateral half of the body over those on the other: dominance in function of one of a pair of lateral homologous parts studies of the laterality of individuals in the performance of different tasks." So, laterality is the asymmetry of bilateral structures or biases in behavior in ...

Human pluripotent stem cells in regenerative medicine Vrije Universiteit Brussel

Ha Thi Nguyen, Kurt Jacobs, Claudia Spits

Human pluripotent stem cells have the capacity to self-renew indefinitely and the ability to differentiate into all cell types of a human body. These characteristics instill them with an enormous promise in regenerative medicine, where they could be used in cell, tissue and even organ-based replacement therapy. In this review, we discuss their potential clinical applications and the advantages and pitfalls for the different types of human ...

Optimizing the European regulatory framework for sustainable bacteriophage therapy in human medicine KU Leuven

Gilbert Verbeken, Rob Lavigne, Minne Casteels, Isabelle Huys
For practitioners at hospitals seeking to use natural (not genetically modified, as appearing in nature) bacteriophages for treatment of antibiotic-resistant bacterial infections (bacteriophage therapy), Europe's current regulatory framework for medicinal products hinders more than it facilitates. Although many experts consider bacteriophage therapy to be a promising complementary (or alternative) treatment to antibiotic therapy, no ...

Generic Workflow to Predict Medicine Concentrations in Human Milk Using Physiologically-Based Pharmacokinetic (PBPK) Modelling—A Contribution from the ConcePTION Project KU Leuven

Nina Nauwelaerts, Miao-Chan Huang, Martje Van Neste, Anne Smits, Karel Allegaert, Pieter Annaert
Women commonly take medication during lactation. Currently, there is little information about the exposure-related safety of maternal medicines for breastfed infants. The aim was to explore the performance of a generic physiologically-based pharmacokinetic (PBPK) model to predict concentrations in human milk for ten physiochemically diverse medicines. First, PBPK models were developed for "non-lactating" adult individuals in PK-Sim/MoBi v9.1 ...