Publicaties
Human blood outgrowth endothelial cells improve islet survival and function when co-transplanted in a mouse model of diabetes Vrije Universiteit Brussel
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CD99 as surface anchor for human islet endocrine cell purification Vrije Universiteit Brussel
Rat and human beta cell proteomes were quantified by liquid chromatography–mass spectrometry/mass spectrometry (LC-MS/MS), searching for cell surface markers. In human beta cells, CD99 (cluster of differentiation 99) was ranked among the plasma membrane proteins that combine a high molar abundance with a relative degree of selectivity for the endocrine cells of the islets of Langerhans. Therefore, the applicability of CD99 as anchor for islet ...
Reversal of hyperglycemia in diabetic mice by a marginal islet mass together with human blood outgrowth endothelial cells is independent of the delivery technique and blood clot-induced processes Universiteit Antwerpen KU Leuven Vrije Universiteit Brussel
Heterogeneity of human pancreatic islet isolation around Europe Vrije Universiteit Brussel
groups are actually achieving similar good outcomes. Further collaborative advances in the field require the standardization
of islet cell product isolation processes, and this work aimed to identify differences in the human pancreatic islet isolation
processes within European countries. Methods. A ...
Pancreatic duct cells in human islet cell preparations are a source of angiogenic cytokines interleukin-8 and vascular endothelial growth factor Vrije Universiteit Brussel
Transplantation of human embryonic stem cell-derived pancreatic endoderm reveals a site-specific survival, growth and differentiation. Vrije Universiteit Brussel
SLC30A8 polymorphism and BMI complement HLA-A*24 as risk factors for poor graft function in islet allograft recipients Vrije Universiteit Brussel KU Leuven
Aims/hypothesis: HLA-A*24 carriership hampers achievement of insulin independence in islet allograft recipients. However, less than half of those who fail to achieve insulin independence carry the allele. We investigated whether genetic polymorphism at the recipients’ zinc transporter 8-encoding SLC30A8 gene (rs13266634) could complement their HLA-A*24 status in predicting functional graft outcome. Methods: We retrospectively analysed data of ...