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The HUPO Brain Proteome project wish list : summary of the 9th HUPO BPP Workshop 9-10 January 2008, Barbados Universiteit Gent
The Human Brain Proteome Project (HUPO BPP) aims at advancing knowledge and the understanding of neurodiseases and aging with the purpose of identifying prognostic and diagnostic biomarkers, as well as to push new diagnostic approaches and medications. The participating groups meet in semi-annual workshops to discuss the progress, as well as the needs, within the field of proteomics. The 9(th) HUPO BPP workshop took place in Barbados from 9-10 ...
Stem-cell-derived human microglia transplanted into mouse brain to study human disease KU Leuven Universiteit Antwerpen Vlaams Instituut voor Biotechnologie
Microglia are critically involved in complex neurological disorders with a strong genetic component, such as Alzheimer's disease, Parkinson's disease and frontotemporal dementia. Although mouse microglia can recapitulate aspects of human microglia physiology, they do not fully capture the human genetic aspects of disease and do not reproduce all human cell states. Primary cultures of human microglia or microglia derived from human induced ...
Identifying the Effects of Visceral Interoception on Human Brain Connectome: A Multivariate Analysis of Covariance of fMRI Data KU Leuven
Sources of variations in the neural circuitry of the human brain and interrelationship between intrinsic connectivity networks (ICNs) are still a matter of debate and ongoing research. Here, we applied a multivariate analysis of covariance (MANCOVA) based on high-dimensional independent component analysis (ICA) to identify the effects of interoception and related variables on human brain connectome. Fifteen healthy right-handed subjects (all ...
Large-scale analysis of neuronal oscillations in the human brain during resting state KU Leuven
Functional connectivity studies allow the investigation of functional interactions that occur in the brain when perception, cognition and action are required. Nowadays these techniques are mainly applied on fMRI (functional Magnetic Resonance Imaging) and MEG (Magnetoencephalography) data to retrieve brain networks, represented as maps where neuronal activity is similar and correlated. However, both fMRI and MEG acquisition systems have some ...
Analysis of the experimental detection of central nervous system-related genes in human brain and cerebrospinal fluid datasets Universiteit Gent
Large-scale and high-throughput proteomics experiments of specific samples provide substantial amounts of identified proteins and peptides, which increasingly find their way into centralized, public data repositories. These data typically have potential beyond the analyses performed by the original authors, and can therefore provide considerable added value by being reused for specific, unexplored enquiries. We here reanalyze two CNS-related ...
Towards animal surrogates for characterising large strain dynamic mechanical properties of human brain tissue KU Leuven
The regional dynamic mechanical properties of mouse, rat, pig, and human brain tissue were compared directly in this first-of-its-kind study. Our results suggest the use of pig or mouse brain tissue as suitable surrogates to characterise human brain tissue. The importance of this work is highlighted by the extensive use of constitutive data from animal brain tissue in traumatic brain injury research in the absence of human brain tissue data ...
Detecting large-scale networks in the human brain using high-density electroencephalography KU Leuven
High-density electroencephalography (hdEEG) is an emerging brain imaging technique that can be used to investigate fast dynamics of electrical activity in the healthy and the diseased human brain. Its applications are however currently limited by a number of methodological issues, among which the difficulty in obtaining accurate source localizations. In particular, these issues have so far prevented EEG studies from reporting brain networks ...
Spatiotemporal models of invasive and noninvasive EEG recordings during abstract and concrete word processing in the human brain KU Leuven
N400 studies have been conducted to assess whether consumers judge a new product as member of a known brand (i.e., brand extension). However, as these studies rely in their analysis on predefined mental categories (brands, product categories): what happens when they are not predefined and even context-dependent? Can we measure with the N400 the effect of marketing stimuli on mental category formation? The aim of this project is to to answer ...