Publicaties
Hippocampal seizures differentially modulate locus coeruleus activity and result in consistent time-locked release of noradrenaline in rat hippocampus Vrije Universiteit Brussel Universiteit Gent
The locus coeruleus (LC) is a small brainstem nucleus and is the sole source of noradrenaline in the neocortex, hippocampus and cerebellum. Noradrenaline is a powerful neuromodulator involved in the regulation of excitability and plasticity of large-scale brain networks. In this study, we performed a detailed assessment of the activity of locus coeruleus neurons and changes in noradrenergic transmission during acute hippocampal seizures ...
Hippocampal deep brain stimulation reveals decreased rCBF in the hippocampus of the rat: a mu spect study Universiteit Gent
Chemogenetic activation of the locus coeruleus increases noradrenaline levels in the hippocampus and modulates its hippocampal excitability Universiteit Gent
Enhancement of extracellular noradrenalin concenration and suppression of pilocarpine-induced seizures in the left hippocampus after vagus nerve stimulation Vrije Universiteit Brussel
Although vagus nerve stimulation is known to suppress seizures and is an approved treatment for refractory epilepsy, its mechanism of action is still unclear. Enhancement of noradrenalin release in the hippocampus, through noradrenergic projections from the locus coeruleus, might contribute to the anti-convulsive effect of VNS. We examined the effects of VNS on pilocarpine-induced limbic seizures and on hippocampal extracellular ...
Neuropeptide Y increases extracellular glutamate concentration in the hippocampus Vrije Universiteit Brussel
from presynaptic terminals. This hypothesis, which was advanced on the basis of in vitro observations, has not been verified in vivo. In the
present study, we used intracerebral microdialysis to determine the effect of NPY on hippocampal extracellular glutamate concentration in
vivo, and ...
Loss of system x(c)- does not induce oxidative stress but decreases extracellular glutamate in hippocampus and influences spatial working memory and limbic seizure susceptibility Vrije Universiteit Brussel
System x(c)- exchanges intracellular glutamate for extracellular cystine, giving it a potential role in intracellular glutathione synthesis and nonvesicular glutamate release. We report that mice lacking the specific xCT subunit of system x(c)- (xCT(-/-)) do not have a lower hippocampal glutathione content, increased oxidative stress or brain atrophy, nor exacerbated spatial reference memory deficits with aging. Together these results ...