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Hedgehog signals inhibit postnatal beta cell neogenesis from adult rat exocrine pancreas in vitro Vrije Universiteit Brussel
Aims/hypothesis Transdifferentiation of pancreatic exocrine cells into insulin-producing beta cells may represent an important alternative to islets required for diabetes cell therapy. Rat pancreatic acinar cells are known to transdifferentiate into functional beta cells, with recapitulation of several pancreas developmental features. Considering the inhibitory functions of hedgehog signalling in early and mid-stage pancreatic development, we ...
Targeting the Hedgehog pathway in combination with X‑ray or carbon ion radiation decreases migration of MCF‑7 breast cancer cells Universiteit Hasselt KU Leuven
The use of carbon ion therapy for cancer treatment is becoming more widespread due to the advantages of carbon ions compared with X-rays. Breast cancer patients may benefit from these advantages, as the surrounding healthy tissues receive a lower dose, and the increased biological effectiveness of carbon ions can better control radioresistant cancer cells. Accumulating evidence indicates that the Hedgehog (Hh) pathway is linked to the ...
The Combination of Particle Irradiation With the Hedgehog Inhibitor GANT61 Differently Modulates the Radiosensitivity and Migration of Cancer Cells Compared to X-Ray Irradiation Universiteit Hasselt KU Leuven
Due to the advantages of charged particles compared to conventional radiotherapy, a vast increase is noted in the use of particle therapy in the clinic. These advantages include an improved dose deposition and increased biological effectiveness. Metastasis is still an important cause of mortality in cancer patients and evidence has shown that conventional radiotherapy can increase the formation of metastasizing cells. An important pathway ...
Hedgehog signals in pancreatic differentiation from embryonic stem cells: revisiting the neglected Vrije Universiteit Brussel
Recent demonstrations of insulin expression by progenies of mouse and human embryonic stem (ES) cells have attracted interest in setting up these cells as alternative sources of b-cells needed in diabetes cell therapy. It is widely acknowledged that information gathered in the field of developmental biology as applied to the pancreas is of relevance for designing in
vitro differentiation strategies. However, looking back at the protocols ...
vitro differentiation strategies. However, looking back at the protocols ...
Nonspecific arboviral haemagglutination inhibitors in hedgehog sera Instituut voor Tropische Geneeskunde
Two new parasitic mites (Acari, Astigmata) from the Algerian hedgehog Aethechinus algirus in Spain Instituut voor Tropische Geneeskunde
Zoonotic pathogens linked with hedgehog diphtheric disease Instituut voor Landbouw-, Visserij- en Voedingsonderzoek Universiteit Gent
Hedgehog diphtheric disease (HDD), an ulcerative skin disease with a high fatality rate, is an emerging threat to European hedgehogs (Erinaceus europaeus). We explored the potential role of a panel of zoonotic pathogens in the presumed multifactorial nature of HDD in 188 hedgehogs from 3 wildlife rescue centres in Belgium. As expected, and with a prevalence of 67% in 57 hedgehogs with skin lesions, characteristic of HDD, the occurrence of ...
Hedgehog signaling sensitizes Glioma stem cells to endogenous nano-irradiation KU Leuven
The existence of therapy resistant glioma stem cells is responsible for the high recurrence rate and incurability of glioblastomas. The Hedgehog pathway activity plays an essential role for self-renewal capacity and survival of glioma stem cells. We examined the potential of the Sonic hedgehog ligand for sensitizing of glioma stem cells to endogenous nano-irradiation. We demonstrate that the Sonic hedgehog ligand preferentially and efficiently ...
The influence of egg size and colour on egg consumption by the Algerian hedgehog (**Atelerix algirus**) Universiteit Antwerpen
We tested the hypothesis that the Algerian hedgehog (Atelerix algirus) consumes smaller eggs in preference to larger ones and that the colour of the eggs (brown or white spotted) does not influence the egg consumption rate. Eggs of three galliform species (the quail, Coturnix japonica; the red legged partridge, Alectoris rufa; the chicken, Gallus domesticus) were offered to 14 individual hedgehogs under experimental conditions. Overall, the ...