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PARP inhibitor predictive value of the Leuven HRD test compared with Myriad MyChoice CDx PLUS HRD on 468 ovarian cancer patients from the PAOLA-1/ENGOT-ov25 trial. Vlaams Instituut voor Biotechnologie KU Leuven
Crystal structure of the Bloom's syndrome helicase indicates a role for the HRDC domain in conformational changes Vrije Universiteit Brussel
Bloom's syndrome helicase (BLM) is a member of the RecQ family of DNA helicases, which play key roles in the maintenance of genome integrity in all organism groups. We describe crystal structures of the BLM helicase domain in complex with DNA and with an antibody fragment, as well as SAXS and domain association studies in solution. We show an unexpected nucleotide-dependent interaction of the core helicase domain with the conserved, poorly ...
Grid voltage control with distributed generation using online grid impedance estimation Universiteit Gent
Grid voltage control with wind turbine inverters by using grid impedance estimation Universiteit Gent
Currently, distributed generation (DG) units usually do not participate in the primary grid voltage control and inject power regardless. Only when the grid voltage level surpasses a certain threshold, these units shut down to avoid any overvoltage problems. In this paper, a method is developed to control the grid voltage by wind turbines. This way, the grid voltage level improves, and the wind turbine can still generate power under suboptimal ...
Homologous recombination repair deficiency (HRD) testing in newly diagnosed advanced-stage epithelial ovarian cancer Universiteit Antwerpen Universiteit Gent KU Leuven
Ovarian cancer (OC) has a poor prognosis as most patients present with non-specific symptoms and the disease is mostly diagnosed at advanced stages. Approximately 90% of cases are classified as epithelial OC (EOC), a category comprising histologically and molecularly distinct tumours. Identifying reliable biomarkers and employing personalised therapies in OC subgroups is crucial for battling the disease. EOCs are often characterised by ...