Publicaties
Transposons Vrije Universiteit Brussel KU Leuven
Transposons have emerged as promising vectors for gene therapy that can potentially overcome some of the limitations of commonly used viral vectors. Transposons stably integrate into the target cell genome, enabling persistent expression of therapeutic genes. Transposons have evolved from being used as basic tools in biomedical research to bona fide therapeutics. Currently, the most promising transposons for gene therapy applications are ...
Moving gene therapy forward with mobile DNA. Vrije Universiteit Brussel
Emerging potential of transposons for gene therapy and generation of induced pluripotent stem cells. Vrije Universiteit Brussel
Recombinant lactic acid bacteria as mucosal biotherapeutic agents Vrije Universiteit Brussel
The safety status of lactic acid bacteria (LAB) and their capacity to survive the passage through the gastrointestinal tract (GI tract) have rendered them excellent candidates for the production of therapeutic proteins and their delivery in situ to the GI tract. During the past two decades, major health benefits of mucosally administered recombinant LAB have been successfully demonstrated, predominantly using animal models. However, the field ...
Dynamics of antigenemia and transmission intensity of Wuchereria bancrofti following cessation of mass drug administration in a formerly highly endemic region of Mali Instituut voor Tropische Geneeskunde
BACKGROUND: After seven annual rounds of mass drug administration (MDA) in six Malian villages highly endemic for Wuchereria bancrofti (overall prevalence rate of 42.7%), treatment was discontinued in 2008. Surveillance was performed over the ensuing 5 years to detect recrudescence.
METHODS: Circulating filarial antigen (CFA) was measured using immunochromatographic card tests (ICT) and Og4C3 ELISA in 6-7 year-olds. Antibody to the W. ...
Trends and predictors of transmitted drug resistance (TDR) and clusters with TDR in a local Belgian HIV-1 epidemic KU Leuven
Intestinal Organoids in Inflammatory Bowel Diseases KU Leuven
The etiology of the aromatase inhibitor-induced musculoskeletal syndrome in breast cancer patients KU Leuven
Imported malaria and artemisinin-based combination therapy failure in travellers returning to Belgium: a retrospective study Instituut voor Tropische Geneeskunde Universiteit Hasselt
Background: Malaria (Plasmodium spp) remains a top cause of travel-associated morbidity among European residents. Here, we describe recent trends of imported malaria to Belgium and characterize the first cases of P. falciparum failure to artemisinin-based combination therapy (ACT).
Methods: National surveillance data and registers from national reference laboratory were used to investigate malaria cases and ACT failures in the past 20 ...