Correction: Reducing phenolic off-flavors through CRISPR-based gene editing of the FDC1 gene in Saccharomyces cerevisiae x Saccharomyces eubayanus hybrid lager beer yeasts. KU Leuven
One small edit for humans, one giant edit for humankind? Points and questions to consider for a responsible way forward for gene editing in humans KU Leuven
Responsible innovation in human germline gene editing : background document to the recommendations of ESHG and ESHRE Universiteit Gent
Human germline gene editing : recommendations of ESHG and ESHRE Universiteit Gent
Efficient In Vivo Liver-Directed Gene Editing Using CRISPR/Cas9 Vrije Universiteit Brussel
In vivo tissue-specific genome editing at the desired loci is still a challenge. Here, we report that AAV9-delivery of truncated guide RNAs (gRNAs) and Cas9 under the control of a computationally designed hepatocyte-specific promoter lead to liver-specific and sequence-specific targeting in the mouse factor IX (F9) gene. The efficiency of in vivo targeting was assessed by T7E1 assays, site-specific Sanger sequencing, and deep sequencing of ...