Contemporary diagnostic challenges in general internal medicine: focus on updating the approach to fever and inflammation of unknown origin KU Leuven
Fever of unknown origin (FUO) and inflammation of unknown origin (IUO) are challenging clinical syndromes characterized by a duration of at least 3 weeks, either fever of 38.3°C (FUO) or elevated inflammatory markers without high-grade fevers (IUO) on several occasions, and no diagnosis despite a baseline workup. The underlying causes are typically categorized as infections, malignancies, noninfectious inflammatory disorders, and miscellaneous ...