Publicaties
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Correcting for non-periodic behaviour in perturbative experiments: application to heat pulse propagation and modulated gas-puff experiments Vrije Universiteit Brussel
This paper introduces a recent innovation in dealing with non-periodic behavior often referred to as transients in perturbative experiments. These transients can be the result from the unforced response due to the initial condition and other slow trends in the measurement data and are a source of error when performing and interpreting Fourier spectra. Fourier analysis is particularly relevant in system identification used to build feedback ...
Experimental evolution of dispersal : unifying theory, experiments and natural systems Universiteit Gent
Dispersal is a central life history trait that affects the ecological and evolutionary dynamics of populations and communities. The recent use of experimental evolution for the study of dispersal is a promising avenue for demonstrating valuable proofs of concept, bringing insight into alternative dispersal strategies and trade-offs, and testing the repeatability of evolutionary outcomes. Practical constraints restrict experimental evolution ...
Optimal experimental design in animal experiments Vrije Universiteit Brussel
Lab animal experiments are quite a unique environment from a statistical perspective. Within the life sciences context, the researchers have a high degree of control over the experimental design.For instance, all the subjects can be chosen to have the same age, to have a specific geneticprofile, to follow the same diet, have identical housing conditions, and siblings can be assigned todifferent experimental conditions. These are just some of the ...
Comparing design of experiments and optimal experimental design techniques for modelling the microbial growth rate under static environmental conditions Universiteit Antwerpen KU Leuven
Building secondary models that describe the growth rate as a function of multiple environmental conditions is often very labour intensive and costly. As such, the current research aims to assist in decreasing the required experimental effort by studying the efficacy of both design of experiments (DOE) and optimal experimental designs (OED) techniques. This is the first research in predictive microbiology (i) to make a comparison of these ...
Alternative experimental design with an applied normalization scheme can improve statistical power in 2D-DIGE experiments KU Leuven Universiteit Gent Universiteit Antwerpen
2D-DIGE experiments are a high-throughput technique for measuring protein abundances based on gel separation. Traditionally three samples are multiplexed per gel: two biological test samples and a third internal standard sample consisting of a pool of all test samples. We demonstrate that the use of an internal standard helps to account for technical variation caused by spatial intensity biases that exist in the gels and propose a novel ...
Experimental salt marsh islands: a model system for novel metacommunity experiments Vrije Universiteit Brussel
Shallow tidal coasts are characterised by shifting tidal flats and emerging or eroding islands above the high tide line. Salt marsh vegetation colonising new habitats distant from existing marshes are an ideal model to investigate metacommunity theory. We installed a set of 12 experimental salt marsh islands made from metal cages on a tidal flat in the German Wadden Sea to study the assembly of salt marsh communities in a metacommunity context. ...
A new modeling method for determining electrochemical parameters from LSV experiments using the stochastic noise. Part II: Experimental validation KU Leuven
A novel modeling procedure to accurately determine the characteristic parameters of an electrochemical reaction from polarization curves, presented in the first part of this series, is validated now on voltammetry experiments. The combination of the local polynomial model and the analytical fitting allows determining the electrochemical parameters (rate constants, charge transfer coefficients, etc.) from one polarization curve. Linear sweep ...
A new modeling method for determining electrochemical parameters from LSV experiments using the stochastic noise. Part II: Experimental validation Vrije Universiteit Brussel
A novel modeling procedure to accurately determine the characteristic parameters of an electrochemical reaction from polarization curves, presented in the first part of this series, is validated now on voltammetry experiments. The combination of the local polynomial model and the analytical fitting allows determining the electrochemical parameters (rate constants, charge transfer coefficients, etc.) from one polarization curve. Linear sweep ...
Orientational distribution of DPH in lipid membranes: a comparison of molecular dynamics calculations and experimental time-resolved anisotropy experiments Universiteit Hasselt
Characterization of the membrane phases is a crucial task in cell biology. Cells differ in composition of the lipids and consequently in adopted phases. The phases can be discriminated based upon lipid ordering and molecular diffusion and their identification could be used for characterization of cell membranes. Here we used molecular dynamics (MD) simulations to study the behavior of the fluorescent reporter molecule diphenylhexatriene (DPH) in ...