Publicaties

Having short changeover times is becoming more and more important in manufacturing operations. Decreasing lot sizes, shorter lead times, lower inventories are all characteristics of lean production systems. A good changeover performance of the manufacturing equipment is a key enabler for this. In reality machine designs are not always made with a fast changeover capability in mind. So, production people are often forced to use IE techniques such ...

Continuous twin screw wet granulation is one of the key continuous manufacturing technologies that have gained significant interest in the pharmaceutical industry as well as in academia over the last ten years. Given its considerable advantages compared to wet granulation techniques operated in batch mode such as high shear granulation and fluid bed granulation, several equipment manufacturers have designed their own manufacturing setup. This ...

The drying unit of a continuous from-powder-to-tablet manufacturing line based on twin-screw granulation (TSG) is a crucial intermediate process step to achieve the desired tablet quality. Understanding the size reduction of pharmaceutical granules before, during, and after the fluid bed drying process is, however, still lacking. A first major goal was to investigate the breakage and attrition phenomena during transport of wet and dry granules, ...

In this research, a novel shear test equipment was developed and finally used in a validity check with neat and reinforced polymers with a subsequent exemplary case study to investigate the short- and long-term shear behavior of two commercially available polymer-based injection mortar systems. A shear testing device was designed and implemented to be used on a universal testing machine allowing shear tests on standardized multipurpose specimens ...

The aim of the study was to investigate whether performance of children can be improved by training with modified equipment that challenges movement execution. For that purpose, young field hockey players practiced with a modified and a regular hockey ball. The modified hockey ball enforces more variable movement execution during practice by rolling less predictably than a regular hockey ball and, thus, challenges the players' stick-ball ...

The fast evolution of networks, techniques and tools makes designing the business case for a new high tech customer offer a collaborative task, in which multiple specialized firms each provide their own expertise to the offer, making it as such the most advanced, yet cost-effective on the market. While in the past, the design of such a business case was made using the "back of an envelope" calculation, the complexity such collaborative effort ...