Publicaties
Humane studies over de rol van de cannabinoidreceptoren en fosfodiesterase 10A enzyme in neurodegeneratieve ziekten. KU Leuven
Balancing Specificity and Promiscuity in Enzyme Evolution Vrije Universiteit Brussel
Highly proficient, promiscuous enzymes can be springboards for functional evolution, able to avoid loss of function during adaptation by their capacity to promote multiple reactions. We employ a systematic comparative study of structure, sequence, and substrate specificity to track the evolution of specificity and reactivity between promiscuous members of clades of the alkaline phosphatase (AP) superfamily. ...
Towards toxin PEGylation: The example of rCollinein-1, a snake venom thrombin-like enzyme, as a PEGylated biopharmaceutical prototype KU Leuven
Summer warming accelerates sub-arctic peatland nitrogen cycling without changing enzyme pools or microbial community structure Universiteit Antwerpen
Presence of VIP, CGRP, SP neuropeptides and PAF-AH enzyme in porcine colostrumstar, open Universiteit Antwerpen
Enzyme immunoassays (EIAs) for the detection of anti-Haemophilus ducreyi serum IgA, IgG, and IgM antibodies Instituut voor Tropische Geneeskunde
Influence of the cellular environment on ligand binding kinetics at membrane-bound targets Vrije Universiteit Brussel
While historically 'in vitro' binding data were obtained by analyzing equilibrium experiments, kinetic data are increasingly appreciated to provide information on the time a particular compound remains bound to its target. This information is of biological importance to understand the molecular mechanism of a drug not only to evaluate the time a particular receptor/enzyme is blocked in the case of antagonists/inhibitors but also to ...