Publicaties
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Engineered vasculature for cancer research and regenerative medicine Universiteit Gent
Measurement and characterization of engineered titanium dioxide nanoparticles in the environment Universiteit Gent
Development of engineered cementitious composites with limestone powder and blast furnace slag Universiteit Gent
Thermochemical upcycling of food waste into engineered biochar for energy and environmental applications : a critical review Universiteit Gent
Environmental issues caused by food waste are important concerns for human well-being and ecosystem health. Valorization of food waste into energy and carbon materials has been extensively investigated. Here, we reviewed the most recent advancements in the thermochemical conversion of food waste into engineered biochar. Synthesis routes and practical applications of the food waste-derived biochar was succinctly reviewed. Engineered biochar is a ...
Targeting the tsetse-trypanosome interplay using genetically engineered Sodalis glossinidius Vrije Universiteit Brussel Universiteit Antwerpen Instituut voor Tropische Geneeskunde Vlaams Instituut voor Biotechnologie
Sodalis glossinidius, a secondary bacterial symbiont of the tsetse fly, is currently considered as a potential delivery system for anti-trypanosomal components interfering with African trypanosome transmission (i.e. paratransgenesis). Nanobodies (Nbs) have been proposed as potential candidates to target the parasite during development in the tsetse fly. In this study, we have generated an immune Nb-library and developed a panning strategy to ...
A VersaTile driven platform for rapid hit-to-lead development of engineered lysins KU Leuven Universiteit Gent
Healthcare authorities are calling for new antibacterial therapies to cope with the global emergence of antibiotic-resistant bacteria. Bacteriophage-encoded lysins are a novel class of antibacterials with promising (pre)clinical progress. Custom engineering of lysins allows for the creation of variants against potentially any bacterial pathogen. We here present a high-throughput hit-to-lead development platform for engineered lysins. The ...
An Ectopic Imaging Window for Intravital Imaging of Engineered Bone Tissue KU Leuven
Tissue engineering is a promising branch of regenerative medicine, but its clinical application remains limited because thorough knowledge of the in vivo repair processes in these engineered implants is limited. Common techniques to study the different phases of bone repair in mice are destructive and thus not optimal to gain insight into the dynamics of this process. Instead, multiphoton-intravital microscopy (MP-IVM) allows visualization of ...
NanoGenotoxicology: The DNA damaging potential of engineered nanomaterials KU Leuven
With the rapid expansion in the nanotechnology industry, it is essential that the safety of engineered nanomaterials and the factors that influence their associated hazards are understood. A vital area governing regulatory health risk assessment is genotoxicology (the study of genetic aberrations following exposure to test agents), as DNA damage may initiate and promote carcinogenesis, or impact fertility. Of late, considerable attention has ...
Tissue engineered heart valve for aortic valve disease Universiteit Antwerpen
Introduction: Heart valve tissue engineering has been presented as a promising solution for over 20 years. These living devices are supposed to have the capacity to grow, heal and repair or remodel. This would avoid structural valve degeneration of currently used biological heart valve prostheses or the need for life-long anticoagulation or mechanical devices. Especially for patients with stenotic aortic valve disease, which is the third most ...