Publicaties
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Generation of cell polarity in plants links endocytosis, auxin distribution and cell fate decisions Universiteit Gent
Dynamically polarized membrane proteins define different cell boundaries and have an important role in intercellular communication - a vital feature of multicellular development. Efflux carriers for the signalling molecule auxin from the PIN family(1) are landmarks of cell polarity in plants and have a crucial involvement in auxin distribution- dependent development including embryo patterning, organogenesis and tropisms(2-7). Polar PIN ...
Differential regulation of clathrin and its adaptor proteins during membrane recruitment for endocytosis Universiteit Gent
Clathrin adaptor complex AP-2 mediates endocytosis of BRASSINOSTEROID INSENSITIVE1 in Arabidopsis Universiteit Gent
Polar-localized NPH3-like proteins regulate polarity and endocytosis of PIN-FORMED auxin efflux carriers Universiteit Gent
Systematic analysis of specific and nonspecific auxin effects on endocytosis and trafficking Universiteit Gent
The phytohormone auxin and its directional transport through tissues are intensively studied. However, a mechanistic understanding of auxin-mediated feedback on endocytosis and polar distribution of PIN auxin transporters remains limited due to contradictory observations and interpretations. Here, we used state-of-the-art methods to reexamine the auxin effects on PIN endocytic trafficking. We used high auxin concentrations or longer treatments ...
High affinity nanobodies against the Trypanosome brucei VSG are potent trypanolytic agents that block endocytosis Instituut voor Tropische Geneeskunde
The African trypanosome Trypanosoma brucei, which persists within the bloodstream of the mammalian host, has evolved potent mechanisms for immune evasion. Specifically, antigenic variation of the variant-specific surface glycoprotein (VSG) and a highly active endocytosis and recycling of the surface coat efficiently delay killing mediated by anti-VSG antibodies. Consequently, conventional VSG-specific intact immunoglobulins are non-trypanocidal ...
Meeting report: Cellular gateways : expanding the role of endocytosis in plant development Universiteit Gent
The occasion of The Company of Biologists' workshop 'Cellular gateways: expanding the role of endocytosis in plant development' on 22-25 April 2018, at Wiston House, an Elizabethan mansion in West Sussex, England, witnessed stimulating and lively discussions on the mechanism and functions of endocytosis in plant cells. The workshop was organized by Jenny Russinova, Daniel Van Damme (both VIB/University of Ghent, Belgium) and Takashi Ueda ...
Involvement of clathrin-dependent endocytosis in cellular dsRNA uptake in aphids Universiteit Gent
RNAi is an essential technology for studying gene function in eukaryotes, and is also considered to be a potential strategy for pest control. However, the mechanism behind the cellular uptake of dsRNA in aphids, a group of important agricultural sucking pests, remains unknown. Here, using the pea aphid Acyrthosiphon pisum as model for aphids, we identified two core genes of clathrin-dependent endocytosis (CDE), Apchc and Apvha16. We confirmed ...