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Discontinuation of continuation or maintenance electroconvulsive therapy caused by the COVID-19 pandemic : a naturalistic study investigating relapse in patients with major depressive disorder Universiteit Gent
Background Continuation or maintenance electroconvulsive therapy (C/M-ECT) is recommended to reduce relapse rates of patients with major depressive disorder. During the ongoing COVID-19 pandemic, ECT services have come under pressure or needed to close because of redirected resources and safety reasons. We investigated the impact of C/M-ECT discontinuation on relapse in patients with unipolar depressive disorder in Flanders, Belgium.Methods ...
Neuroplasticity-related genes and dopamine receptors associated with regional cortical thickness increase following electroconvulsive therapy for major depressive disorder Universiteit Gent Vrije Universiteit Brussel
Electroconvulsive therapy (ECT) is an effective neuromodulatory therapy for major depressive disorder (MDD). Treatment is associated with regional changes in brain structure and function, indicating activation of neuroplastic processes. To investigate the underlying neurobiological mechanism of macroscopic reorganization following ECT, we longitudinally (before and after ECT in two centers) collected magnetic resonance images for 96 MDD ...
Prolonged seizure duration of electroconvulsive therapy in a patient pre-stimulated with transcranial direct current stimulation Vrije Universiteit Brussel Universiteit Gent
Cognitive remediation following electroconvulsive therapy in patients with treatment resistant depression : randomized controlled trail of an intervention for relapse prevention : study protocol Universiteit Gent Vrije Universiteit Brussel
Background: Major depressive episode (MDE) is worldwide one of the most prevalent and disabling mental health conditions. In cases of persistent non-response to treatment, electroconvulsive therapy (ECT) is a safe and effective treatment strategy with high response rates. Unfortunately, longitudinal data show low sustained response rates with 6-month relapse rates as high as 50% using existing relapse prevention strategies. Cognitive side ...
Concurrent use of lamotrigine and electroconvulsive therapy Universiteit Gent KU Leuven
OBJECTIVE: To evaluate the effect of lamotrigine (LMT) on electroconvulsive therapy (ECT)-induced seizures. METHODS: Charts of all patients receiving LMT while undergoing an ECT course from July 2001 through May 2009 were reviewed. Apart from demographic variables, data collection consisted of diagnosis, indication for ECT, index or continuation ECT, electrode placement, stimulus dose, motor and electroencephalographic seizure duration, LMT ...
BDNF blood levels after electroconvulsive therapy in patients with mood disorders: a systematic review and meta-analysis Universiteit Gent
Objectives. To evaluate whether electroconvulsive therapy (ECT), a very effective non-pharmacological treatment for mood disorders, induces neurotrophic effects, indexed by the measurement of peripheral brain-derived neurotrophic factor (BDNF) levels. Methods. Systematic review and meta-analysis of clinical trials published in PubMed/Medline from the first date available to October 2013. We included studies measuring pre- and post-BDNF blood ...
Prediction of electroconvulsive therapy response and remission in major depression Vrije Universiteit Brussel Universiteit Antwerpen
BACKGROUND: Electroconvulsive therapy (ECT) is considered to be the most effective treatment in severe major depression. The identification of reliable predictors of ECT response could contribute to a more targeted patient selection and consequently increased ECT response rates. Aims To investigate the predictive value of age, depression severity, psychotic and melancholic features for ECT response and remission in major depression.
...Psychotic late-life depression less likely to relapse after electroconvulsive therapy KU Leuven
BACKGROUND: A substantial number of patients with late-life depression (LLD) that remitted after ECT experience relapse. Identifying risk factors for relapse may guide clinical management to devote attention to those at increased risk. Therefore the current study aims to evaluate which baseline clinical characteristics are related to relapse within six months after successful ECT in patients with severe LLD. METHODS: 110 patients with LLD from ...