Publicaties
Gekozen filters:
Gekozen filters:
Epigenetics in toxicology: the implications of epigenetic alterations driven by external exposures for human health Vrije Universiteit Brussel
The prospect that non-genotoxic environmental exposures of physical, chemical or social nature act on epigenetic mechanisms opens a new emerging field in toxicology. Epigenetics refers to the stable changes in gene expression programming that could alter the phenotype in absence of a change in DNA sequence. Epigenetic modifications, which include amongst others DNA methylation, covalent modifications of histone tails, and regulation by ...
Comprehensive histone epigenetics : a mass spectrometry based screening assay to measure epigenetic toxicity Universiteit Gent
Evidence of the involvement of epigenetics in pathologies such as cancer, diabetes, and neurodegeneration has increased global interest in epigenetic modifications. For nearly thirty years, it has been known that cancer cells exhibit abnormal DNA methylation patterns. In contrast, the large-scale analysis of histone post-translational modifications (hPTMs) has lagged behind because classically, histone modification analysis has relied on site ...
Hippocampal and cortical tissue-specific epigenetic clocks indicate an increased epigenetic age in a mouse model for Alzheimer's disease KU Leuven
Epigenetic clocks are based on age-associated changes in DNA methylation of CpG-sites, which can accurately measure chronological age in different species. Recently, several studies have indicated that the difference between chronological and epigenetic age, defined as the age acceleration, could reflect biological age indicating functional decline and age-associated diseases. In humans, an epigenetic clock associated Alzheimer's disease (AD) ...
Age-associated epigenetic change in chimpanzees and humans: Chimpanzee Epigenetic Age Koninklijke Maatschappij voor Dierkunde van Antwerpen
Methylation levels have been shown to change with age at sites across the human genome. Change at some of these sites is so consistent across individuals that it can be used as an ‘epigenetic clock’ to predict an individual's chronological age to within a few years. Here, we examined how the pattern of epigenetic ageing in chimpanzees compares with humans. We profiled genome-wide blood methylation levels by microarray for 113 samples from 83 ...
Dynamiek en ethiek van de epigenetica Universiteit Antwerpen
Epigenetica en obesitas KU Leuven
Conrad Waddington (1905-1975) : epigenetica als de nieuwe embryologie Universiteit Gent
Epigenetic regulation : the cross-talk among development, adaptive strategies, and microevolutionary change Universiteit Gent
In this chapter, we aim to demonstrate that epigenetic regulation is a central, cohesive and comprehensive process that underpins, reflects in and brings together developmental aspects, phenotypic responses and inheritance that may constrain evolutionary pathways. In particular, evidence on the critical role of epigenetics in developmental biology was compiled, which demonstrates that, despite the stability of such processes, epigenetic ...