Publicaties

Purpose Urothelium has 2 main functions. It is a barrier to urine and has a sensory role. In response to stretch urothelium releases various substances that modulate afferent nerve activity. Recent data on the localization of cyclooxygenase type 1, the enzyme responsible for prostaglandin production, suggests that prostaglandin may have complex local action. Materials and Methods The bladders of 7 guinea pigs were stained for prostaglandin ...

The European Patent Office Enlarged Board of Appeal was asked in April 2019 to answer two questions regarding the exclusions from patentability under Art. 53 European Patent Convention (EPC), the dominant patent law in Europe. The first related to the manner in which EPC Articles should be interpreted, and the second to whether Art. 53 EPC excluded plants and animals that are the products of the excluded "essentially biological processes." Since ...

Axillary lymph node involvement is an important prognostic factor for breast cancer survival but is confounded by the number of nodes examined. We compare the performance of the log odds prognostic index (Lpi), using a ratio of the positive versus negative lymph nodes, with the Nottingham Prognostic Index (NPI) for short-term breast cancer specific disease free survival. A total of 1818 operable breast cancer patients treated in the University ...

OBJECTIVES: The purpose of our study was to evaluate the use of 2D-selective, parallel-transmit excitation magnetic resonance imaging (MRI) for diffusion-weighted echo-planar imaging (pTX-EPI) of the prostate, and to compare it to conventional, single-shot EPI (c-EPI). METHODS: The MRI examinations of 35 patients were evaluated in this prospective study. PTX-EPI was performed with a TX-acceleration factor of 1.7 and a field of view (FOV) of ...

Echo planar imaging (EPI) is an ultrafast magnetic resonance imaging (MRI) technique that allows one to acquire a 2D image in about 100 ms. Unfortunately, the standard EPI images suffer from substantial geometric distortions, mainly originating from susceptibility differences in adjacent tissues. To reduce EPI distortions, correction methods based on a field map, which is a map of the off-resonance frequencies, have been developed. In this work, ...

In the present paper we discuss an alternative pre-epi clean method, which is performed at a reduced temperature of 600°C, while maintaining SiO 2 removal efficiency of the conventional H 2 preepi bake at 800-900°C. It is essentially an ex-situ HF-dip followed by a GeH4 - -enhanced Si etch that is performed in-situ in an epi reactor. The etch process lifts-off residual SiO 2 together with a very thin well controlled top layer of crystalline Si. ...

The clinical application of diffusion MRI is practically hindered by its long scan time. In this work, we introduce a novel imaging and parameter estimation framework for time-efficient diffusion MRI. To improve the scan efficiency, we propose ADEPT (Accelerated Diffusion EPI with multi-contrast shoTs), in which diffusion contrast settings are allowed to change between shots in a multi-shot EPI acquisition (i.e. intra-scan modulation). The ...

© 2018 Wiley-VCH Verlag GmbH & Co. KGaA, Weinheim In a search for novel vitamin D derivatives of potential therapeutic value, structurally simple but synthetically challenging A-ring epimers of the 19-nor-Calcitriol [19-nor-1α,25-(OH)2-D3] at C1 and C3 were efficiently synthesized. Both analogues (1-epi- and 3-epi-19-nor-Calcitriol) were obtained through a convergent synthesis starting from cis,cis-1,3,5-cyclohexanetriol and the protected ...

Background: The Kenyan Ministry of Public Health and Sanitation was the first in Africa to introduce the new 10-valent Pneumococcal Conjugate Vaccine, PCV-10, in 2011. For successful implementation and to avoid adverse events following immunisation, specific training on handling and storage of the PCV-10 vaccine was required. Therefore, a training DVD was recorded in English and partly in Kiswahili to be used in combination with in-classroom ...