Publicaties
Bactericidal coating to prevent early and delayed implant-related infections KU Leuven
Injectables' key role in rifampicin-resistant tuberculosis shorter treatment regimen outcomes Instituut voor Tropische Geneeskunde
Background
Since a meta-analysis showed little or no effect of second-line injectables on treatment success, and using injectables may induce ototoxicity, injectable-free rifampicin-resistant tuberculosis (RR-TB) treatment regimens are recommended. However, acquired resistance preventing activity was overlooked. No previous study assessed the effect of shortening the duration of kanamycin administration to 2 months during the ...
Gatifloxacin for short, effective treatment of multidrug-resistant tuberculosis Instituut voor Tropische Geneeskunde
The 9-month regimen for the treatment of multidrug-resistant tuberculosis (MDR-TB) piloted in Bangladesh and used, with modifications, in Cameroon and Niger, has achieved treatment success in a very large proportion of patients; gatifloxacin (GFX) is likely to have played a critical role in this success. Two months after the publication of a study reporting that GFX and not moxifloxacin (MFX) was associated with dysglycaemia, the manufacturer ...
Pretomanid for tuberculosis: a systematic review Instituut voor Tropische Geneeskunde
BACKGROUND: Outcomes of treatment of tuberculosis patients with regimens including pretomanid have not yet been systematically reviewed.
OBJECTIVES: To appraise existing evidence on efficacy and safety of pretomanid in tuberculosis.
DATA SOURCES: Pubmed, clinicaltrials.gov. and Cochrane library.
STUDY ELIGIBILITY CRITERIA: Quantitative studies presenting original data on clinical efficacy or safety of pretomanid.
...Tuberculosis clinical trial update and the current anti-tuberculosis drug portfolio Universiteit Gent
Acquired bedaquiline resistance during the treatment of drug-resistant tuberculosis: a systematic review Instituut voor Tropische Geneeskunde
BACKGROUND: Drug-resistant tuberculosis (DR-TB) is considered to be a public health threat and is difficult to cure, requiring a lengthy treatment with potent, potentially toxic drugs. The novel antimicrobial agent bedaquiline has shown promising results for patients with DR-TB, improving the rate of culture conversion and reducing TB-related mortality. However, increasing numbers of cases with acquired bedaquiline resistance (ABR) have been ...
Mycobactericidal effects of different regimens measured by molecular bacterial load assay among people treated for multidrug-resistant tuberculosis in Tanzania Instituut voor Tropische Geneeskunde
Rifampin or multidrug-resistant tuberculosis (RR/MDR-TB) treatment has largely transitioned to regimens free of the injectable aminoglycoside component, despite the drug class' purported bactericidal activity early in treatment. We tested whether Mycobacterium tuberculosis killing rates measured by tuberculosis molecular bacterial load assay (TB-MBLA) in sputa correlate with composition of the RR/MDRTB regimen. Serial sputa were collected ...