The present invention relates to methods to protect grafts against cell death due to preservation of said grafts prior to transplanting these grafts into patients. In particular, the present invention discloses that connexin channel inhibitors can be used to protect against cell death associated with preservation and temporary storage of cells, tissues and organs. Preservation includes any procedure that involves a lowering of the temperature below the normal body temperature, including hypothermia (cold storage), cryopreservation and vitrification. Grafts that are protected according to the ...