Soluble CD26 / dipeptidyl peptidase IV enhances human lymphocyte proliferation **in vitro** independent of dipeptidyl peptidase enzyme activity and adenosine deaminase binding Universiteit Antwerpen
Human CD26 has dipeptidyl peptidase-4 (DPP IV) enzyme activity and binds to adenosine deaminase (ADA). CD26 is costimulatory for lymphocytes and has a circulating soluble form (sCD26). DPP IV enzyme inhibition is a new successful type 2 diabetes therapy. We examined whether the ADA binding and catalytic functions of sCD26 contribute to its effects on T-cell proliferation. Wildtype soluble recombinant human CD26 (srhCD26), an enzyme inactive ...