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Deafness caused by didanosine [letter] Instituut voor Tropische Geneeskunde
The application of Mitsunobu cyclization for the synthesis of 2 ',3 '-dideoxy-C-nucleosides designed as didanosine analogues KU Leuven
The synthesis of new 2',3'-dideoxy-C-nucleosides structurally related to didanosine has been achieved. Their preparation involved condensation of a Suitably substituted, lithiated 2- or 4-picoline with 2',3'-dideoxy-5'-benzylribonolactone, followed by borohydride reduction of the resulting hemiacetals, intramolecular Mitsunobu cyclization of the derived diols, formation of the pyrazolo[3,4-c] or [4,3-b]pyridine ring-system and Subsequent removal ...
Pancreatitis in an HIV-infected person on a tenofovir, didanosine and stavudine containing highly active antiretroviral treatment [letter] Instituut voor Tropische Geneeskunde
Dinucleoside polyphosphates : newly detected uraemic compounds with an impact on leucocyte oxidative burst Universiteit Gent
Background. Dinucleoside polyphosphates (NpnN) have pathophysiologic roles in cardiovascular disease and are newly detected uraemic retention solutes. They were retrieved in human plasma, tissues and cells. Although their impact on several cell systems involved in vascular damage (endothelium, smooth muscle cells and thrombocytes) has been evaluated, their effect on different types of leucocytes has never been studied. Methods. This study ...
Antiretroviral treatment in the private sector in Namibia Instituut voor Tropische Geneeskunde
Antiretroviral treatment (ART) has been available in the private sector in Namibia since 1998. National guidelines were developed by the Ministry of Health and clinicians of the public and private sector in 2003 and launched at the start of the public sector ART programme by the Ministry of Health. The Namibian HIV Clinicians Society was established around this period to promote adherence to the national guidelines and to provide comprehensive ...
What is the optimal first line antiretroviral therapy in resource-limited settings? [comment] Instituut voor Tropische Geneeskunde
Evaluation de la prophylaxie post-exposition Instituut voor Tropische Geneeskunde
Structural insights into HIV reverse transcriptase mutations Q151M and Q151M complex that confer multinucleoside drug resistance KU Leuven
HIV-1 reverse transcriptase (RT) is targeted by multiple drugs. RT mutations that confer resistance to nucleoside RT inhibitors (NRTIs) emerge during clinical use. Q151M and four associated mutations, A62V, V75I, F77L, and F116Y, were detected in patients failing therapies with dideoxynucleosides (didanosine [ddI], zalcitabine [ddC]) and/or zidovudine (AZT). The cluster of the five mutations is referred to as the Q151M complex (Q151Mc), and an ...
Dipeptidyl Peptidase IV (DPPIV/CD26)-Based Prodrugs of Hydroxy-Containing Drugs KU Leuven Universiteit Antwerpen
We previously described a novel prodrug approach in which a di- or tetrapeptide moiety is linked to a wide variety of amine-containing drugs through an amide bond, which is specifically cleaved by dipeptidyl peptidase IV (DPPIV/CD26) activity. Herein we report the application of this prodrug approach to a variety of hydroxy-containing drugs (primary, secondary, tertiary, or aromatic hydroxy groups). We designed and studied tripartite prodrugs ...