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Activity-state dependent reversal of ketamine-induced resting state EEG effects by clozapine and naltrexone in the freely moving rat Universiteit Antwerpen

Christien Bowman, Ulrike Richter, Christopher R. Jones, Claus Agerskov, Kjartan Frisch Herrik
Ketamine is a non-competitive N-Methyl-D-aspartate receptor (NMDAR) antagonist used in the clinic to initiate and maintain anaesthesia; it induces dissociative states and has emerged as a breakthrough therapy for major depressive disorder. Using local field potential recordings in freely moving rats, we studied resting state EEG profiles induced by co-administering ketamine with either: clozapine, a highly efficacious antipsychotic; or ...

Response to "A controversial consensus"; By the International Consensus Panel Vrije Universiteit Brussel

Gordon Broderick, Kenny De Meirleir, B. Carruthers, M. Van De Sande
Dear Sir,First and foremost, we would like to thank Drs van der Meer and Lloyd [1] for their careful and thorough review of the International Consensus Criteria (ICC) paper [2]. We support this type of open discussion and strongly agree that only in this way will the basic and clinical science of myalgic encephalomyelitis (ME)/chronic fatigue syndrome (CFS) evolve soundly. This being said the content of their feedback also leads us to believe ...

The neurobiology of motor symptoms in late life depression. KU Leuven

Margot Van Cauwenberge
Psychomotor dysfunction (PMD) is a symptom dimension of major depressive disorder that is particularly common in late life depression (LLD) and leads to falls. Its neurobiology remains unresolved. Accelerated aging or neurodegeneration in the brain's motor regions could explain the severity of motor symptoms in LLD. Recently developed PET imaging techniques allow to study the brain's neuronal synaptic density, which is typically affected in key ...

Pharmacotherapy and nutritional supplements for seasonal affective disorders Vrije Universiteit Brussel Universiteit Antwerpen

Olivia Cools, Kaat Hebbrecht, Violette Coppens, Laurence Roosens, Manuel Morrens, Hugo Neels, Bernard Sabbe

INTRODUCTION: A seasonal affective disorder (SAD) is a subtype of unipolar and bipolar major depressive disorders. It is characterized by its annual recurrence of depressive episodes at a particular season, mostly seen in winter and is responsible for 10-20% of the prevalence of major depressive disorders. Some pathophysiological hypotheses, such as the phase delay and the monoamine depletion hypotheses, have been postulated but the exact ...

EEG connectivity between the subgenual anterior cingulate and prefrontal cortices in response to antidepressant medication Vrije Universiteit Brussel Universiteit Gent

Tabitha A Iseger, Mayuresh S Korgaonkar, J Leon Kenemans, Stuart M Grieve, Chris Baeken, Martijn Arns

Antidepressant medication is the most common treatment for major depressive disorder (MDD), however, the precise working mechanism underlying these treatments remains unclear. Recent neuromodulation treatments demonstrate that direct stimulation of the dorsolateral prefrontal cortex (DLPFC), dorsomedial prefrontal cortex (DMPFC), and subgenual anterior cingulate (sgACC) relate to clinical improvement, suggesting connectivity alterations of ...

Accelerated Repetitive Transcranial Magnetic Stimulation to Treat Major Depression Vrije Universiteit Brussel

Leo Chen, Deborah C W Klooster, Martin Tik, Elizabeth H X Thomas, Jonathan Downar, Nolan R Williams, Chris Baeken

Repetitive transcranial magnetic stimulation (rTMS) is an effective and evidence-based therapy for treatment-resistant major depressive disorder. A conventional course of rTMS applies 20-30 daily sessions over 4-6 weeks. The schedule of rTMS delivery can be accelerated by applying multiple stimulation sessions per day, which reduces the duration of a treatment course with a predefined number of sessions. Accelerated rTMS reduces time demands, ...

HF-rTMS treatment in medication-resistant melancholic depression: results from 18FDG-PET brain imaging. Vrije Universiteit Brussel

Chris Baeken, Rudi De Raedt, C. Van Hove, Peter Clerinx, Johan De Mey
INTRODUCTION: High frequency repetitive transcranial magnetic stimulation (HF-rTMS) of the left dorsolateral prefrontal cortex (DLPFC) might be a promising strategy to treat depression, but not all patients show a positive outcome.

OBJECTIVE: In this open study, we evaluate whether a favorable HF-rTMS treatment outcome could be predicted by baseline prefrontal brain glucose metabolism (CMRglc), measured by 18fluorodeoxyglucose ...

Evaluation of vilazodone for the treatment of depressive and anxiety disorders Universiteit Antwerpen

Mirella Stuivenga, Erik Giltay, Olivia Cools, Laurence Roosens, Hugo Neels, Bernard Sabbe
Introduction: Major Depressive Disorder (MDD) and General Anxiety Disorder (GAD) significantly contribute to the global burden of disease. Vilazodone, a combined serotonin reuptake inhibitor and 5-HT1A partial agonist, is an approved therapy for the treatment of MDD and which has been further investigated for GAD. Areas covered: This article covers the pharmacokinetics and pharmacodynamics of vilazodone and provides an evaluation of the clinical ...