Secretion and functional display of fusion proteins through the curli biogenesis pathway Vrije Universiteit Brussel
Curli are functional amyloids expressed as fibers on the surface of Enterobacteriaceae. Contrary to the protein misfolding events associated with pathogenic amyloidosis, curli are the result of a dedicated biosynthetic pathway. A specialized transporter in the outer membrane, CsgG, operates in conjunction with the two accessory proteins CsgE and CsgF to secrete curlin subunits to the extracellular surface, where they nucleate into cross-beta ...